PuSH - Publication Server of Helmholtz Zentrum München: Methylation status of <em>VTRNA2-1</em>/<em>nc886</em> is stable across populations, monozygotic twin pairs and in majority of tissues.

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Marttila, S.* ; Tamminen, H.* ; Rajić, S.* ; Mishra, P.P.* ; Lehtimäki, T.* ; Raitakari, O.* ; Kähönen, M.* ; Kananen, L.* ; Jylhävä, J.* ; Hägg, S.* ; Delerue, T. ; Peters, A. ; Waldenberger, M. ; Kleber, M.E.* ; März, W.* ; Luoto, R.* ; Raitanen, J.* ; Sillanpää, E.* ; Laakkonen, E.K.* ; Heikkinen, A.* ; Ollikainen, M.* ; Raitoharju, E.*

Methylation status of VTRNA2-1/nc886 is stable across populations, monozygotic twin pairs and in majority of tissues.

Epigenomics 14, 1105-1124 (2022)

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Aims & methods: The aim of this study was to characterize the methylation level of a polymorphically imprinted gene, VTRNA2-1/nc886, in human populations and somatic tissues.48 datasets, consisting of more than 30 tissues and >30,000 individuals, were used. Results: nc886 methylation status is associated with twin status and ethnic background, but the variation between populations is limited. Monozygotic twin pairs present concordant methylation, whereas ∼30% of dizygotic twin pairs present discordant methylation in the nc886 locus. The methylation levels of nc886 are uniform across somatic tissues, except in cerebellum and skeletal muscle. Conclusion: The nc886 imprint may be established in the oocyte, and, after implantation, the methylation status is stable, excluding a few specific tissues.

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