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Galle, E.* ; Wong, C.W.* ; Ghosh, A.* ; Desgeorges, T.* ; Melrose, K.* ; Hinte, L.C.* ; Castellano-Castillo, D.* ; Engl, M.* ; de Sousa, J.A.* ; Ruiz Ojeda, F.J. ; de Bock, K.* ; Ruiz, J.R.* ; von Meyenn, F.*

H3K18 lactylation marks tissue-specific active enhancers.

Genome Biol. 23:207 (2022)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
BACKGROUND: Histone lactylation has been recently described as a novel histone post-translational modification linking cellular metabolism to epigenetic regulation. RESULTS: Given the expected relevance of this modification and current limited knowledge of its function, we generate genome-wide datasets of H3K18la distribution in various in vitro and in vivo samples, including mouse embryonic stem cells, macrophages, adipocytes, and mouse and human skeletal muscle. We compare them to profiles of well-established histone modifications and gene expression patterns. Supervised and unsupervised bioinformatics analysis shows that global H3K18la distribution resembles H3K27ac, although we also find notable differences. H3K18la marks active CpG island-containing promoters of highly expressed genes across most tissues assessed, including many housekeeping genes, and positively correlates with H3K27ac and H3K4me3 as well as with gene expression. In addition, H3K18la is enriched at active enhancers that lie in proximity to genes that are functionally important for the respective tissue. CONCLUSIONS: Overall, our data suggests that H3K18la is not only a marker for active promoters, but also a mark of tissue specific active enhancers.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Adipocyte ; Cut&tag ; Chromhmm ; Embryonic Stem Cell ; Enhancer ; Epigenetics ; H3k18la ; Histone Post-translational Modification ; Lactate ; Lactylation ; Macrophage ; Muscle ; Promoter
ISSN (print) / ISBN 1474-760X
e-ISSN 1465-6906
Journal Genome Biology
Quellenangaben Volume: 23, Issue: 1, Pages: , Article Number: 207 Supplement: ,
Publisher BioMed Central
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)
Grants Fondation Botnar
Future Food Initiative