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Early life dynamics of ARG and MGE associated with intestinal virome in neonatal piglets.
Vet. Microbiol. 274:109575 (2022)
The pre- and post-weaning stages for piglets are critical periods for the maturation of intestinal functions and contamination with antibiotic resistant bacterial pathogens will threaten their intestinal health. The presence of bacteriophage can also alter bacterial populations in the intestine but whether transmission of antibiotic resistance genes (ARG) is affected by phage during maturation of the neonatal piglet intestine is not known. We therefore identified the intestinal virome along with ARGs and mobile genetic elements (MGE) from piglet fecal samples collected from 3 to 28 days representing the different growth stages. We found wide fluctuations for the intestinal virome of weaning piglets and most virus - related antibiotic resistance was derived from temperate phage suggesting a reservoir of multidrug resistance was present in the neonatal porcine gut. Our results provide a comprehensive understanding of ARGs associated with the intestinal virome that therefore represents a potential risk for horizontal ARG transfer to pathogenic bacteria.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Arg ; Intestinal Virome ; Mge ; Multidrug Resistance ; Neonatal Piglets
ISSN (print) / ISBN
0378-1135
e-ISSN
1873-2542
Journal
Veterinary Microbiology
Quellenangaben
Volume: 274,
Article Number: 109575
Publisher
Elsevier
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Virology (VIRO)
Grants
Natural Science Foundation of Guangdong Province
Guangdong Major Project of Basic and Applied Basic Research
Guangdong Major Project of Basic and Applied Basic Research