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Diversity of fibroblasts and their roles in wound healing.
Cold Spring Harbor Perspect. Biol. 15:a041222 (2023)
Wound healing disorders are a societal, clinical, and healthcare burden and understanding and treating them is a major challenge. A particularly important cell type in the wound healing processes is the fibroblast. Fibroblasts are not homogenous; however, there are diverse functional fibroblast subtypes coming from different embryonic origins and residing in dispersed anatomic locations including distinct classes of fibroblasts at various skin depths. In this review, we discuss the implications of fibroblast heterogeneity, with a focus on the fundamental physiological functions of the fibroblast subtypes that govern wound repair and clinical degrees of healing. A better understanding of these diverse functional fibroblast populations will likely lead to novel therapies to enhance wound healing and inhibit excessive scarring.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Granulation-tissue; Regeneration; Skin; Myofibroblasts; Contraction; Compendium; Mechanism; Burden
e-ISSN
1943-0264
Quellenangaben
Volume: 15,
Issue: 3,
Article Number: a041222
Publisher
Cold Spring Harbor Laboratory Press
Publishing Place
1 Bungtown Rd, Cold Spring Harbor, Ny 11724 Usa
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Regenerative Biology (IRBM)
Grants
European Foundation for the Study of Diabetes (EFSD)
LEO Foundation
European Research Council
Fritz-Thyssen-Stiftung
German Research Foundation
Human Frontier Science Program Career Development Award
LEO Foundation
European Research Council
Fritz-Thyssen-Stiftung
German Research Foundation
Human Frontier Science Program Career Development Award