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Kampfer, S.* ; Dobiasch, S. ; Combs, S.E. ; Wilkens, J.J.*

Comparison of 3 positioning techniques for fractionated high-precision radiotherapy in an orthotopic mouse model of pancreatic cancer.

Comparative Med. 72, 336-341 (2022)

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Small-animal irradiators are widely used in oncologic research, and many experiments use mice to mimic radiation treatments in humans. To improve fractionated high-precision irradiation in mice with orthotopic pancreatic tumors, we evaluated 3 positioning methods: no positioning aid, skin marker, and immobilization devices (immobilization masks). We retrospectively evaluated the translation vector needed for optimal tumor alignment (by shifting the mouse in left-right, in cranio-caudal, and in anterior-posterior direction) on cone-beam CT from our small-animal radiotherapy system. Of the 3 methods, the skin marker method yielded the smallest mean translation vector (3.8 mm) and was the most precise method overall for most of the mice. In addition, the skin marker method required supplemental rotation (that is, roll, pitch, and yaw) for optimal tumor alignment only half as often as positioning without a positioning aid. Finally, the skin marker method had the highest scores for the quality of the fusion results. Overall, we preferred the skin marker method over the other 2 positioning methods with regard to optimal treatment planning and radiotherapy in an orthotopic mouse model of pancreatic cancer.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Small-animal Immobilizer; Irradiation

ISSN (print) / ISBN 1532-0820

e-ISSN 1532-0820

Journal Comparative Medicine

Quellenangaben Volume: 72, Issue: 5, Pages: 336-341

Publisher American Association for Laboratory Animal Science (AALAS)

Publishing Place 9190 Crestwyn Hills Dr, Memphis, Tn 38125 Usa

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Radiation Medicine (IRM)

Grants Helmholtz Zentrum Munchen ("Translational & Clinical Projects")
KKF Program for the Medical Faculty of the Technical University of Munich
Hans and Klementia Langmatz Foundation
Deutsche Forschungsgemeinschaft (German Research Foundation)