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A pathophysiological intersection of diabetes and alzheimer's disease.
Int. J. Mol. Sci. 23:11562 (2022)
Diabetes is among the most prevalent diseases of the modern world and is strongly linked to an increased risk of numerous neurodegenerative disorders, although the exact pathophysiological mechanisms are not clear yet. Insulin resistance is a serious pathological condition, connecting type 2 diabetes, metabolic syndrome, and obesity. Recently, insulin resistance has been proven to be connected also to cognitive decline and dementias, including the most prevalent form, Alzheimer's disease. The relationship between diabetes and Alzheimer's disease regarding pathophysiology is so significant that it has been proposed that some presentations of the condition could be termed type 3 diabetes.
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Publication type
Article: Journal article
Document type
Review
Keywords
Diabetes ; Insulin Sensitivity ; Alzheimer's Disease ; Brain ; Cognition ; Depression
Language
english
Publication Year
2022
HGF-reported in Year
2022
ISSN (print) / ISBN
1661-6596
e-ISSN
1422-0067
Quellenangaben
Volume: 23,
Issue: 19,
Article Number: 11562
Publisher
MDPI
Publishing Place
Basel
Reviewing status
Peer reviewed
Institute(s)
Institute of Developmental Genetics (IDG)
POF-Topic(s)
30204 - Cell Programming and Repair
Research field(s)
Genetics and Epidemiology
PSP Element(s)
G-500500-001
WOS ID
WOS:000867769900001
Scopus ID
85140018683
PubMed ID
36232867
Erfassungsdatum
2022-11-08