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Lowe, D.* ; Roy, L.* ; Tabocchini, M.A.* ; Rühm, W. ; Wakeford, R.* ; Woloschak, G.E.* ; Laurier, D.*

Radiation dose rate effects: What is new and what is needed?

Radiat. Environ. Biophys. 61, 507-543 (2022)
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Despite decades of research to understand the biological effects of ionising radiation, there is still much uncertainty over the role of dose rate. Motivated by a virtual workshop on the "Effects of spatial and temporal variation in dose delivery" organised in November 2020 by the Multidisciplinary Low Dose Initiative (MELODI), here, we review studies to date exploring dose rate effects, highlighting significant findings, recent advances and to provide perspective and recommendations for requirements and direction of future work. A comprehensive range of studies is considered, including molecular, cellular, animal, and human studies, with a focus on low linear-energy-transfer radiation exposure. Limits and advantages of each type of study are discussed, and a focus is made on future research needs.
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Publication type Article: Journal article
Document type Review
Keywords Dose Rate ; Epidemiology ; Ionising Radiation ; Low-let ; Radiobiology ; Recommendations
Language english
Publication Year 2022
HGF-reported in Year 2022
ISSN (print) / ISBN 0301-634X
e-ISSN 1432-2099
Journal Radiation and Environmental Biophysics
Quellenangaben Volume: 61, Issue: 4, Pages: 507-543 Article Number: , Supplement: ,
Publisher Springer
Reviewing status Peer reviewed
Institute(s) Institute of Radiation Medicine (IRM)
POF-Topic(s) 30203 - Molecular Targets and Therapies
Research field(s) Radiation Sciences
PSP Element(s) G-501391-001
DOI 10.1007/s00411-022-00996-0
WOS ID WOS:000873426000001
Scopus ID 85140085662
PubMed ID 36241855
Erfassungsdatum 2022-11-25
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