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Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes.
BMC Med. Genomics 15:124 (2022)
BACKGROUND: Head circumference is associated with intelligence and tracks from childhood into adulthood. METHODS: We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30 months of age. RESULTS: Seven loci reached genome-wide significance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes. CONCLUSIONS: The results of this study indicate that the biological processes underlying early-life head circumference overlap largely with those of adult head circumference. The associations of early-life head circumference with cognitive outcomes across the life course are partly explained by genetics.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Genetic Correlations ; Genome-wide Association Study ; Head Circumference ; Infancy
e-ISSN
1755-8794
Journal
BMC Medical Genomics
Quellenangaben
Volume: 15,
Issue: 1,
Article Number: 124
Publisher
BioMed Central
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Epidemiology (EPI)
Institute of Epidemiology II (EPI2)
Institute of Translational Genomics (ITG)
Institute of Epidemiology II (EPI2)
Institute of Translational Genomics (ITG)
Grants
NIDDK NIH HHS
NICHD NIH HHS
Wellcome Trust
NICHD NIH HHS
Wellcome Trust