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The legacy of parental obesity: Mechanisms of non-genetic transmission and reversibility.

Biomedicines 10:2461 (2022)
Publ. Version/Full Text DOI PMC
Open Access Gold
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While a dramatic increase in obesity and related comorbidities is being witnessed, the underlying mechanisms of their spread remain unresolved. Epigenetic and other non-genetic mechanisms tend to be prominent candidates involved in the establishment and transmission of obesity and associated metabolic disorders to offspring. Here, we review recent findings addressing those candidates, in the context of maternal and paternal influences, and discuss the effectiveness of preventive measures.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Dohad ; Epigenetics ; Hfd ; Intergenerational Inheritance ; Non-genetic Inheritance ; Obesity ; Pohad ; Reversibility
ISSN (print) / ISBN 2227-9059
e-ISSN 2227-9059
Journal Biomedicines
Quellenangaben Volume: 10, Issue: 10, Pages: , Article Number: 2461 Supplement: ,
Publisher MDPI
Publishing Place Basel, Switzerland
Non-patent literature Publications
Reviewing status Peer reviewed
Grants Helmholtz Association
Fritz Thyssen Stiftung
German Diabetes Research Center