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Comas-Armangue, G. ; Makharadze, L. ; Gómez Velázquez, M. ; Teperino, R.

The legacy of parental obesity: Mechanisms of non-genetic transmission and reversibility.

Biomedicines 10:2461 (2022)
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While a dramatic increase in obesity and related comorbidities is being witnessed, the underlying mechanisms of their spread remain unresolved. Epigenetic and other non-genetic mechanisms tend to be prominent candidates involved in the establishment and transmission of obesity and associated metabolic disorders to offspring. Here, we review recent findings addressing those candidates, in the context of maternal and paternal influences, and discuss the effectiveness of preventive measures.
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Publication type Article: Journal article
Document type Review
Keywords Dohad ; Epigenetics ; Hfd ; Intergenerational Inheritance ; Non-genetic Inheritance ; Obesity ; Pohad ; Reversibility
Language english
Publication Year 2022
HGF-reported in Year 2022
ISSN (print) / ISBN 2227-9059
e-ISSN 2227-9059
Journal Biomedicines
Quellenangaben Volume: 10, Issue: 10, Pages: , Article Number: 2461 Supplement: ,
Publisher MDPI
Publishing Place Basel, Switzerland
Reviewing status Peer reviewed
Institute(s) Institute of Experimental Genetics (IEG)
POF-Topic(s) 90000 - German Center for Diabetes Research
30201 - Metabolic Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-501900-069
G-501900-063
G-500600-001
Grants Helmholtz Association
Fritz Thyssen Stiftung
German Diabetes Research Center
DOI 10.3390/biomedicines10102461
WOS ID WOS:000872332800001
Scopus ID 85140472499
PubMed ID 36289722
Erfassungsdatum 2022-11-03
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