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Aeromonas allosaccharophila strain AE59-TE2 is highly antagonistic towards multidrug-resistant human pathogens, what does its genome tell us?
Life 12:1492 (2022)
Multidrug-resistant bacteria are of critical importance and a problem for human health and food preservation; the discovery of new antimicrobial substances to control their proliferation is part of the solution. This work reports on 57 antagonistic Aeromonas strains, of which 38 strains were antagonistic towards problematic human pathogens. The genome of the most antagonistic strain was sequenced and identified as Aeromonas allosaccharophila. Its genome was fully annotated and mined for genes that might explain that activity. Strain AE59-TE was antagonistic toward clinically relevant gram-negative and gram-positive multidrug-resistant bacteria, including Klebsiella pneumoniae KPC, Escherichia coli ESBL, Salmonella typhimurium, and Staphylococcus aureus MRSA. Strain AE59-TE2 was identified by multilocus sequence analysis. Genome mining identified four genes homologous to the bacteriocin, zoocin A from Streptococcus equi and a gene 98% similar to cvpA linked to colicin V production. A. allosaccharophila strain AE59-TE2 produced antimicrobial activity against a broad range of bacteria, including important gram-negative bacteria, not typically targeted by bacteriocins. Herewere described novel zoocin genes that are promising for industrial applications in the food and health sectors. Interesting and important antagonistic activity is described combined with the first detailed genomic analysis of the species Aeromonas allosaccharophila.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Aeromonas Allosaccharophila ; Antimicrobial Activity ; Antimicrobial Resistance ; Bacteriocins ; Genomics
ISSN (print) / ISBN
2075-1729
e-ISSN
2075-1729
Journal
Life
Quellenangaben
Volume: 12,
Issue: 10,
Article Number: 1492
Publisher
MDPI
Publishing Place
Basel
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Research Unit Comparative Microbiome Analysis (COMI)
Grants
Coordenção de Aperfeiçoamento de Pessoal de Nível Superior
National Council for Scientific and Technological Development
National Council for Scientific and Technological Development