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Tischer, C.* ; Täubel, M.* ; Kirjavainen, P.V.* ; Depner, M. ; Hyvärinen, A.* ; Piippo-Savolainen, E.* ; Pekkanen, J.* ; Karvonen, A.M.*

Early-life residential exposure to moisture damage is associated with persistent wheezing in a Finnish birth cohort.

Pediatr. Allergy Immunol. 33:e13864 (2022)
Publ. Version/Full Text DOI PMC
Open Access Gold (Paid Option)
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Background and Aims: Moisture damage increases the risk for respiratory disorders in childhood. Our aim was to determine whether early age residential exposure to inspector-observed moisture damage or mold is associated with different wheezing phenotypes later in childhood. Methods: Building inspections were performed by civil engineers, in a standardized manner, in the children's homes—mostly single family and row houses (N = 344)—in the first year of life. The children were followed up with repeated questionnaires until the age of 6 years and wheezing phenotypes—never/infrequent, transient, intermediate, late onset, and persistent—were defined using latent class analyses. The multinomial logistic regression model was used for statistical analysis. Results: A total of 63% (n = 218) had infrequent or no wheeze, 23% (n = 80) had transient and 9.6% (n = 21) had a persistent wheeze. Due to the low prevalence, results for intermediate (3.8%, n = 13) and late-onset wheeze (3.5%, n = 12) were not further evaluated. Most consistent associations were observed with the persistent wheeze phenotype with an adjusted odds ratio (95% confidence intervals) 2.04 (0.67–6.18) for minor moisture damage with or without mold spots (present in 23.8% of homes) and 3.68 (1.04–13.05) for major damage or any moisture damage with visible mold in a child's main living areas (present in 13.4% of homes). Early-age moisture damage or mold in the kitchen was associated with transient wheezing. Conclusion: At an early age, residential exposure to moisture damage or mold, can be dose-dependently associated especially with persistent wheezing phenotype later in childhood.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Childhood ; Indoor ; Latent Class Analysis ; Moisture Damage ; Mold ; Wheezing Phenotype; Exhaled Nitric-oxide; 1st 6 Years; Lung-function; Risk-factors; Childhood Wheeze; Asthma; Phenotypes; Atopy; Trajectories; Symptoms
ISSN (print) / ISBN 0905-6157
e-ISSN 1399-3038
Journal Pediatric Allergy and Immunology
Quellenangaben Volume: 33, Issue: 10, Pages: , Article Number: e13864 Supplement: ,
Publisher Wiley
Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Asthma and Allergy Prevention (IAP)
Grants Yrjö Jahnssonin Säätiö
European Commission
EVO- and VTR
Finnish Institute for Health and Welfare
Juho Vainion Säätiö
Päivikki ja Sakari Sohlbergin Säätiö
Suomen Kulttuurirahasto