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Open Access Green as soon as Postprint is submitted to ZB.
The role of virus-specific CD4+ T cells in the control of Epstein-Barr virus infection.
Eur. J. Cell Biol. 91, 31-35 (2012)
Epstein-Barr virus (EBV) establishes lifelong persistent infections in humans and has been implicated in the pathogenesis of several human malignancies. Protective immunity against EBV is mediated by T cells, as indicated by an increased incidence of EBV-associated malignancies in immunocompromised patients, and by the successful treatment of EBV-associated post-transplant lymphoproliferative disease (PTLD) in transplant recipients by the infusion of polyclonal EBV-specific T cell lines. To implement this treatment modality as a conventional therapeutic option, and to extend this protocol to other EBV-associated diseases, generic and more direct approaches for the generation of EBV-specific T cell lines enriched in disease-relevant specificities need to be developed. To this aim, we studied the poorly defined EBV-specific CD4+ T cell response during acute and chronic infection.
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Publication type
Article: Journal article
Document type
Review
Keywords
Epstein-Barr virus; CD4+ T cell; Antigen; Immunodominance; Therapy
ISSN (print) / ISBN
0171-9335
e-ISSN
1618-1298
Journal
European Journal of Cell Biology
Quellenangaben
Volume: 91,
Issue: 1,
Pages: 31-35
Publisher
Elsevier
Non-patent literature
Publications
Reviewing status
Peer reviewed