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Grapin-Botton, A. ; Kim, Y.H.*

Pancreas organoid models of development and regeneration.

Development 149:dev201004 (2022)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Organoids have become one of the fastest progressing and applied models in biological and medical research, and various organoids have now been developed for most of the organs of the body. Here, we review the methods developed to generate pancreas organoids in vitro from embryonic, fetal and adult cells, as well as pluripotent stem cells. We discuss how these systems have been used to learn new aspects of pancreas development, regeneration and disease, as well as their limitations and potential for future discoveries.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords 3d Culture ; Development ; Diabetes Mellitus ; Organoids ; Pancreas ; Regeneration ; Stem Cells
ISSN (print) / ISBN 0950-1991
e-ISSN 1477-9129
Quellenangaben Volume: 149, Issue: 20, Pages: , Article Number: dev201004 Supplement: ,
Publisher Company of Biologists
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute for Pancreatic Beta Cell Research (IPI)
Grants Max-Planck-Gesellschaft

Human Frontier Science Program