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Pancreas organoid models of development and regeneration.
Development 149:dev201004 (2022)
Organoids have become one of the fastest progressing and applied models in biological and medical research, and various organoids have now been developed for most of the organs of the body. Here, we review the methods developed to generate pancreas organoids in vitro from embryonic, fetal and adult cells, as well as pluripotent stem cells. We discuss how these systems have been used to learn new aspects of pancreas development, regeneration and disease, as well as their limitations and potential for future discoveries.
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Publication type
Article: Journal article
Document type
Review
Keywords
3d Culture ; Development ; Diabetes Mellitus ; Organoids ; Pancreas ; Regeneration ; Stem Cells
ISSN (print) / ISBN
0950-1991
e-ISSN
1477-9129
Quellenangaben
Volume: 149,
Issue: 20,
Article Number: dev201004
Publisher
Company of Biologists
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute for Pancreatic Beta Cell Research (IPI)
Grants
Max-Planck-Gesellschaft
Human Frontier Science Program
Human Frontier Science Program