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Xie, K.* ; Fuchs, H. ; Scifo, E.* ; Liu, D.* ; Aziz, A.* ; Aguilar-Pimentel, J.A. ; Amarie, O.V. ; Becker, L. ; da Silva Buttkus, P. ; Calzada-Wack, J. ; Cho, Y.-L. ; Deng, Y.* ; Edwards, A.C.* ; Garrett, L. ; Georgopoulou, C.* ; Gerlini, R. ; Hölter, S.M. ; Klein-Rodewald, T. ; Kramer, M.* ; Leuchtenberger, S. ; Lountzi, D.* ; Mayer-Kuckuk, P. ; Nover, L.L.* ; Oestereicher, M.A. ; Overkott, C.* ; Pearson, B.L.* ; Rathkolb, B. ; Rozman, J. ; Russ, J.* ; Schaaf, K.* ; Spielmann, N. ; Sanz-Moreno, A. ; Stoeger, C. ; Treise, I. ; Bano, D.* ; Busch, D.H.* ; Graw, J. ; Klingenspor, M.* ; Klopstock, T.* ; Mock, B.A.* ; Salomoni, P.* ; Schmidt-Weber, C.B. ; Weiergräber, M.* ; Wolf, E.* ; Wurst, W. ; Gailus-Durner, V. ; Breteler, M.M.B.* ; Hrabě de Angelis, M. ; Ehninger, D.*

Deep phenotyping and lifetime trajectories reveal limited effects of longevity regulators on the aging process in C57BL/6J mice.

Nat. Commun. 13:6830 (2022)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Current concepts regarding the biology of aging are primarily based on studies aimed at identifying factors regulating lifespan. However, lifespan as a sole proxy measure for aging can be of limited value because it may be restricted by specific pathologies. Here, we employ large-scale phenotyping to analyze hundreds of markers in aging male C57BL/6J mice. For each phenotype, we establish lifetime profiles to determine when age-dependent change is first detectable relative to the young adult baseline. We examine key lifespan regulators (putative anti-aging interventions; PAAIs) for a possible countering of aging. Importantly, unlike most previous studies, we include in our study design young treated groups of animals, subjected to PAAIs prior to the onset of detectable age-dependent phenotypic change. Many PAAI effects influence phenotypes long before the onset of detectable age-dependent change, but, importantly, do not alter the rate of phenotypic change. Hence, these PAAIs have limited effects on aging.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Journal Nature Communications
Quellenangaben Volume: 13, Issue: 1, Pages: , Article Number: 6830 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Experimental Genetics (IEG)
Institute of Developmental Genetics (IDG)
Institute for Allergy Research (IAF)
Grants Projekt DEAL