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Klein-Rodewald, T. ; Micklich, K. ; Sanz-Moreno, A. ; Tost, M. ; Calzada-Wack, J. ; Adler, T. ; Klaften, M. ; Sabrautzki, S. ; Aigner, B.* ; Kraiger, M. ; Gailus-Durner, V. ; Fuchs, H. ; German Mouse Clinic Consortium (Aguilar-Pimentel, J.A. ; Becker, L. ; Garrett, L. ; Hölter, S.M. ; Prehn, C. ; Rácz, I. ; Rozman, J. ; Puk, O. ; Schrewe, A. ; Adamski, J. ; Esposito, I. ; Wurst, W. ; Stoeger, C.) ; Gründer, A.* ; Pahl, H.* ; Wolf, E.* ; Hrabě de Angelis, M. ; Rathkolb, B.

New C3H KitN824K/WT cancer mouse model develops late-onset malignant mammary tumors with high penetrance.

Sci. Rep. 12:19793 (2022)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Gastro-intestinal stromal tumors and acute myeloid leukemia induced by activating stem cell factor receptor tyrosine kinase (KIT) mutations are highly malignant. Less clear is the role of KIT mutations in the context of breast cancer. Treatment success of KIT-induced cancers is still unsatisfactory because of primary or secondary resistance to therapy. Mouse models offer essential platforms for studies on molecular disease mechanisms in basic cancer research. In the course of the Munich N-ethyl-N-nitrosourea (ENU) mutagenesis program a mouse line with inherited polycythemia was established. It carries a base-pair exchange in the Kit gene leading to an amino acid exchange at position 824 in the activation loop of KIT. This KIT variant corresponds to the N822K mutation found in human cancers, which is associated with imatinib-resistance. C3H KitN824K/WT mice develop hyperplasia of interstitial cells of Cajal and retention of ingesta in the cecum. In contrast to previous Kit-mutant models, we observe a benign course of gastrointestinal pathology associated with prolonged survival. Female mutants develop mammary carcinomas at late onset and subsequent lung metastasis. The disease model complements existing oncology research platforms. It allows for addressing the role of KIT mutations in breast cancer and identifying genetic and environmental modifiers of disease progression.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2022
HGF-reported in Year 2022
ISSN (print) / ISBN 2045-2322
e-ISSN 2045-2322
Journal Scientific Reports
Quellenangaben Volume: 12, Issue: 1, Pages: , Article Number: 19793 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Experimental Genetics (IEG)
Institute of Developmental Genetics (IDG)
CF Metabolomics & Proteomics (CF-MPC)
Institute of Pathology (PATH)
CF Laboratory Animal Services (CF-LAS)
POF-Topic(s) 30201 - Metabolic Health
30204 - Cell Programming and Repair
30505 - New Technologies for Biomedical Discoveries
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30202 - Environmental Health
Research field(s) Genetics and Epidemiology
Enabling and Novel Technologies
PSP Element(s) G-500692-001
G-500600-001
G-500500-001
A-630710-001
G-500500-002
G-500300-001
A-620000-008
Grants Bundesministerium für Bildung und Forschung
National Genome Research Network
NGFN
MHdA
German Mouse Clinic
German Center for Diabetes Research
DZD
DOI 10.1038/s41598-022-23218-5
WOS ID WOS:000885172100071
Scopus ID 85142133561
PubMed ID 36396684
Erfassungsdatum 2022-11-29
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