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Divaret-Chauveau, A.* ; Mauny, F.* ; Hose, A.* ; Depner, M. ; Dalphin, M.L.* ; Kaulek, V.* ; Barnig, C.* ; Schaub, B.* ; Schmaußer-Hechfellner, E. ; Renz, H.* ; Riedler, J.* ; Pekkanen, J.* ; Karvonen, A.M.* ; Täubel, M.* ; Lauener, R.* ; Roduit, C.* ; Vuitton, D.A.* ; von Mutius, E. ; Demoulin-Alexikova, S.*

Trajectories of cough without a cold in early childhood and associations with atopic diseases.

Clin. Exp. Allergy 53, 429-442 (2022)
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BACKGROUND: Although children can frequently experience a cough that affects their quality of life, few epidemiological studies have explored cough without a cold during childhood. OBJECTIVES: The objective of the study was to describe the latent class trajectories of cough from one to 10 years old and analyse their association with wheezing, atopy and allergic diseases. METHODS: Questions about cough, wheeze and allergic diseases were asked at 1, 1.5, 2, 3, 4, 5, 6 and 10 years of age in the European prospective cohort of Protection against Allergy: STUdy in Rural Environment (PASTURE). Specific IgE assays were performed at 10 years of age. Questions regarding a cough without a cold were used to build a latent class model of cough over time. RESULTS: Among the 961 children included in the study, apart from the never/infrequent trajectory (59.9%), eight trajectories of cough without a cold were identified: five grouped acute transient classes (24.1%), moderate transient (6.8%), late persistent (4.8%) and early persistent (4.4%). Compared with the never/infrequent trajectory, the other trajectories were significantly associated with wheezing, asthma and allergic rhinitis. For asthma, the strongest association was with the early persistent trajectory (ORa  = 31.00 [14.03-68.51]), which was inversely associated with farm environment (ORa  = 0.39 [0.19-0.77]) and had a high prevalence of cough triggers and unremitting wheeze. Late and early persistent trajectories were also associated with food allergy. Atopic sensitization was only associated with the late persistent trajectory. CONCLUSION: Late and early persistent coughs without a cold are positively associated with atopic respiratory diseases and food allergy. Children having recurrent cough without a cold with night cough and triggers would benefit from an asthma and allergy assessment. Growing up on a farm is associated with reduced early persistent cough.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Allergic Diseases ; Asthma ; Atopy ; Childhood ; Cough; Phenotypes; Mechanisms; Children; Wheeze; Asthma
Language english
Publication Year 2022
HGF-reported in Year 2022
ISSN (print) / ISBN 0954-7894
e-ISSN 1365-2222
Journal Clinical & Experimental Allergy
Quellenangaben Volume: 53, Issue: 4, Pages: 429-442 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa
Reviewing status Peer reviewed
Institute(s) Institute of Asthma and Allergy Prevention (IAP)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Allergy
PSP Element(s) G-503300-001
DOI 10.1111/cea.14257
WOS ID 000892676200001
WOS ID WOS:000892676200001
Scopus ID 85144030056
PubMed ID 36453463
Erfassungsdatum 2022-12-08
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