PuSH - Publication Server of Helmholtz Zentrum München: Higher daily air temperature is associated with shorter leukocyte telomere length: KORA F3 and KORA F4.

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Ni, W. ; Wolf, K. ; Breitner-Busch, S. ; Zhang, S. ; Nikolaou, N. ; Ward-Caviness, C.K.* ; Waldenberger, M. ; Gieger, C. ; Peters, A. ; Schneider, A.E.

Higher daily air temperature is associated with shorter leukocyte telomere length: KORA F3 and KORA F4.

Environ. Sci. Technol. 56, 17815-17824 (2022)

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Higher air temperature is associated with increased age-related morbidity and mortality. To date, short-term effects of air temperature on leukocyte telomere length have not been investigated in an adult population. We aimed to examine the short-term associations between air temperature and leukocyte telomere length in an adult population-based setting, including two independent cohorts. This population-based study involved 5864 participants from the KORA F3 (2004-2005) and F4 (2006-2008) cohort studies conducted in Augsburg, Germany. Leukocyte telomere length was assessed by a quantitative PCR-based method. We estimated air temperature at each participant's residential address through a highly resolved spatiotemporal model. We conducted cohort-specific generalized additive models to explore the short-term effects of air temperature on leukocyte telomere length at lags 0-1, 2-6, 0-6, and 0-13 days separately and pooled the estimates by fixed-effects meta-analysis. Our study found that between individuals, an interquartile range (IQR) increase in daily air temperature was associated with shorter leukocyte telomere length at lags 0-1, 2-6, 0-6, and 0-13 days (%change: -2.96 [-4.46; -1.43], -2.79 [-4.49; -1.07], -4.18 [-6.08; -2.25], and -6.69 [-9.04; -4.27], respectively). This meta-analysis of two cohort studies showed that between individuals, higher daily air temperature was associated with shorter leukocyte telomere length.

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