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Würzner, P.* ; Jörres, R.A.* ; Karrasch, S. ; Quartucci, C.* ; Bose-O'Reilly, S.* ; Nowak, D.* ; Rakete, S.*

Effect of experimental exposures to 3-D printer emissions on nasal allergen responses and lung diffusing capacity for inhaled carbon monoxide/nitric oxide in subjects with seasonal allergic rhinitis.

Indoor Air 32:e13174 (2022)

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	Open Access Gold (Paid Option)

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3-D printers are widely used. Based on previous findings, we hypothesized that their emissions could enhance allergen responsiveness and reduce lung diffusing capacity. Using a cross-over design, 28 young subjects with seasonal allergic rhinitis were exposed to 3-D printer emissions, either from polylactic acid (PLA) or from acrylonitrile butadiene styrene copolymer (ABS), for 2 h each. Ninety minutes later, nasal allergen challenges were performed, with secretions sampled after 1.5 h. Besides nasal functional and inflammatory responses, assessments included diffusing capacity. There was also an inclusion day without exposure. The exposures elicited slight reductions in lung diffusing capacity for inhaled nitric oxide (DL_NO ) that were similar for PLA and ABS. Rhinomanometry showed the same allergen responses after both exposures. In nasal secretions, concentrations of interleukin 6 and tumor necrosis factor were slightly reduced after ABS exposure versus inclusion day, while that of interleukin 5 was slightly increased after PLA exposure versus inclusion.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords 3-d Printer Emissions ; Allergic Rhinitis ; Diffusing Capacity Of The Lung ; Exposures Study ; Nanoparticles ; Nasal Allergen Response

ISSN (print) / ISBN 0905-6947

e-ISSN 1600-0668

Journal Indoor Air

Quellenangaben Volume: 32, Issue: 11, Article Number: e13174

Publisher Wiley

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Epidemiology (EPI)

Grants Ludwig Maximilian University