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Kundrát, P.* ; Friedland, W. ; Baiocco, G.*

Track structure-based simulations on DNA damage induced by diverse isotopes.

Int. J. Mol. Sci. 23:13693 (2022)

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Diverse isotopes such as ²H, ³He, ¹⁰Be, ¹¹C and ¹⁴C occur in nuclear reactions in ion beam radiotherapy, in cosmic ray shielding, or are intentionally accelerated in dating techniques. However, only a few studies have specifically addressed the biological effects of diverse isotopes and were limited to energies of several MeV/u. A database of simulations with the PARTRAC biophysical tool is presented for H, He, Li, Be, B and C isotopes at energies from 0.5 GeV/u down to stopping. The doses deposited to a cell nucleus and also the yields per unit dose of single- and double-strand breaks and their clusters induced in cellular DNA are predicted to vary among diverse isotopes of the same element at energies < 1 MeV/u, especially for isotopes of H and He. The results may affect the risk estimates for astronauts in deep space missions or the models of biological effectiveness of ion beams and indicate that radiation protection in ¹⁴C or ¹⁰Be dating techniques may be based on knowledge gathered with ¹²C or ⁹Be.

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