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Allelic imbalances in radiation-associated acute myeloid leukemia.
Genes 2, 384-393 (2011)
Acute myeloid leukemia (AML) can develop as a secondary malignancy following radiotherapy, but also following low-dose environmental or occupational radiation exposure. Therapy-related AML frequently carries deletions of chromosome 5q and/or 7, but for low-dose exposure associated AML this has not been described. For the present study we performed genome-wide screens for loss-of-heterozygosity (LOH) in a set of 19 AML cases that developed after radiation-exposure following the Chernobyl accident. Using Affymetrix SNP arrays we found large regions of LOH in 16 of the cases. Eight cases (42%) demonstrated LOH at 5q and/or 7, which is a known marker of complex karyotypic changes and poor prognosis. We could show here for the first time that exposure to low-dose ionizing radiation induces AML with molecular alterations similar to those seen in therapy-related cases.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
acute myeloid leukemia; ionizing radiation; Chernobyl accident; single nucleotide polymorphism; microarray
ISSN (print) / ISBN
2073-4425
e-ISSN
2073-4425
Journal
Genes
Quellenangaben
Volume: 2,
Issue: 2,
Pages: 384-393
Publisher
MDPI
Non-patent literature
Publications
Reviewing status
Peer reviewed