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Subclinical cardiovascular disease markers in relation to serum and dietary magnesium in individuals from the general population: The KORA-MRI study.
Nutrients 14:4954 (2022)
Several studies have implied a role of magnesium in the development of cardiovascular disease (CVD). Thus, magnesium might serve as a potential risk marker for early CVD. Therefore, we investigated the association of serum magnesium and dietary magnesium intake with markers of subclinical CVD in a population-based study. We used cross-sectional data from the sub-study of the Cooperative Health Research in the Region of Augsburg (KORA-FF4). Markers of subclinical CVD, namely, left and right ventricular structure and function and carotid plaque and carotid wall thickness, were derived by magnetic resonance imaging (MRI). Multivariable-adjusted regression models were applied to assess the relationship between serum and dietary magnesium and MRI-derived subclinical CVD markers. Among 396 included participants (mean age: 56.3 ± 9.2 years; 57.8% male), 181 (45.7%) had low serum magnesium levels (<2.07 mg/dL). Among 311 subjects with complete dietary data (mean age: 56.3 ± 9.1 years; 56.3% male), 154 (49.5%) had low dietary magnesium intake (≤155.2 mg/1000 kcal/day). Serum and dietary magnesium were not correlated (p-value = 0.5). Serum magnesium was significantly associated with presence of carotid plaque (OR 1.62, p-value 0.033). Dietary magnesium was associated with higher left ventricular end-systolic and end-diastolic volume (0.04 mL/m2, 0.06 mL/m2; p-value 0.011, 0.013, respectively), and also with a decrease in left ventricular remodeling index and mean diastolic wall thickness (−0.001 g/mL/m2, −0.002 mm/m2; p-value 0.004, 0.029, respectively). In summary, there was no consistent association of serum and dietary magnesium with imaging markers of subclinical CVD.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Cardiac Mri ; Early Cardiac Impairment ; Magnesium ; Preclinical Atherosclerosis; Coronary-heart-disease; Risk-factors; Global Burden; Atherosclerosis; Thickness; Inflammation; Metaanalysis; Dysfunction
ISSN (print) / ISBN
2072-6643
e-ISSN
2072-6643
Journal
Nutrients
Quellenangaben
Volume: 14,
Issue: 23,
Article Number: 4954
Publisher
MDPI
Publishing Place
Basel
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Epidemiology II (EPI2)
Grants
Helmholtz Zentrum Munchen
Bundesministerium für Bildung und Forschung
Deutsche Forschungsgemeinschaft
German Centre for Cardiovascular Disease Research
Bundesministerium für Bildung und Forschung
Deutsche Forschungsgemeinschaft
German Centre for Cardiovascular Disease Research