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Roquin-dependent gene regulation in immune-mediated diseases and future therapies.
Int. Immunol. 35, 159-170 (2022)
The RNA-binding proteins Roquin-1/2 and Regnase-1 exert essential regulation by controlling proinflammatory mRNA expression to prevent autoimmune disease. More recently, inhibition of this post-transcriptional gene regulatory program has been demonstrated to enable enhanced anti-tumor responses by tumor antigen-specific CD8 + T cells. In this review we describe the functions of these RNA-binding proteins and the phenotypes that arise in association with genetic inhibition or inactivation. We discuss how inducible inactivation of the system reprograms CD4 + and CD8 + T cell fates by changing cell metabolism, activation, differentiation or effector/memory decisions. We furthermore outline what we need to know to precisely modulate this system in order to dampen autoimmune reactions or boost the efficacy of adoptively transferred T cells or chimeric antigen receptor (CAR) T cells in cancer immunotherapies.
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Publication type
Article: Journal article
Document type
Review
Keywords
Regnase-1 ; Autoimmunity ; Autoinflammation ; Cancer Therapy ; Post-transcriptional Gene Regulation
Language
english
Publication Year
2022
HGF-reported in Year
2022
ISSN (print) / ISBN
0953-8178
e-ISSN
1460-2377
Journal
International Immunology
Quellenangaben
Volume: 35,
Issue: 4,
Pages: 159-170
Publisher
Oxford University Press
Reviewing status
Peer reviewed
Institute(s)
Research Unit Molecular Immune Regulation (AMIR)
POF-Topic(s)
30203 - Molecular Targets and Therapies
Research field(s)
Immune Response and Infection
PSP Element(s)
G-501712-001
Scopus ID
85160242165
PubMed ID
36525589
Erfassungsdatum
2022-12-20