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Babamiri, A.* ; Ahookhosh, K.* ; Abdollahi, H.* ; Taheri, M.H.* ; Cui, X.* ; Nabaei, M.* ; Farnoud, A.

Effect of laryngeal jet on dry powder inhaler aerosol deposition: A numerical simulation.

Comp. meth. biomech. biomed. engin. imag. visual., DOI: 10.1080/10255842.2022.2152280 (2022)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Although pulmonary drug delivery has been deeply investigated, the effect of the laryngeal jet on particle deposition during drug delivery with dry powder inhalers (DPI) has not been evaluated profoundly. In this study, the flow structure and particle deposition pattern of a DPI in two airway models, one with mouth-throat region including the larynx and the other one without it, are numerically investigated. The results revealed that the laryngeal jet has a considerable effect on particle deposition. The presence of laryngeal jet leads to 4-fold and 2-fold higher deposition efficiencies for inlet flow rates of 30 and 90 L/min, respectively.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Cfd ; Laryngeal Jet ; Pulmonary Drug Delivery ; Flow Structure ; Particle Deposition Pattern
ISSN (print) / ISBN 2168-1163
e-ISSN 2168-1171
Journal Computer methods in biomechanics and biomedical engineering : imaging & visualization
Publisher Taylor & Francis
Publishing Place Abingdon
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Computational Biology (ICB)