PuSH - Publication Server of Helmholtz Zentrum München

Bis, J.C.* ; Kavousi, M.* ; Franceschini, N.* ; Isaacs, A.* ; Abecasis, G.R.* ; Schminke, U.* ; Post, W.S.* ; Smith, A.V.* ; Cupples, L.A.* ; Markus, H.S.* ; Schmidt, R.* ; Huffman, J.E.* ; Lehtimäki, T.* ; Baumert, J.J. ; Münzel, T.* ; Heckbert, S.R.* ; Dehghan, A.* ; North, K.* ; Oostra, B.* ; Bevan, S.* ; Stoegerer, E.M.* ; Hayward, C.* ; Raitakari, O.* ; Meisinger, C. ; Schillert, A.* ; Sanna, S.* ; Völzke, H.* ; Cheng, Y.C.* ; Thorsson, B.* ; Fox, C.S.* ; Rice, K.* ; Rivadeneira, F.* ; Nambi, V.* ; Halperin, E.* ; Petrovic, K.E.* ; Peltonen, L.* ; Wichmann, H.-E. ; Schnabel, R.B.* ; Dörr, M.* ; Parsa, A.* ; Aspelund, T.* ; Demissie, S.* ; Kathiresan, S.* ; Reilly, M.P.* ; Taylor, K.* ; Uitterlinden, A.* ; Couper, D.J.* ; Sitzer, M.* ; Kähönen, M.* ; Illig, T. ; Wild, P.S.* ; Orrù, M.* ; Lüdemann, J.* ; Shuldiner, A.R.* ; Eiriksdottir, G.* ; White, C.C.* ; Rotter, J.I.* ; Hofman, A.* ; Seissler, J.* ; Zeller, T.* ; Usala, G.* ; Ernst, F.* ; Launer, L.J.* ; D'Agostino, R.B. Sr.* ; O'Leary, D.H.* ; Ballantyne, C.* ; Thiery, J.* ; Ziegler, A.* ; Lakatta, E.G.* ; Chilukoti, R.K.* ; Harris, T.B.* ; Wolf, P.A.* ; Psaty, B.M.* ; Polak, J.F.* ; Li, X.* ; Rathmann, W.* ; Uda, M.* ; Boerwinkle, E.* ; Klopp, N. ; Schmidt, H.* ; Wilson, J.F.* ; Viikari, J.* ; Koenig, W.* ; Blankenberg, S.* ; Newman, A.B.* ; Witteman, J.* ; Heiss, G.* ; Duijn, C.* ; Scuteri, A.* ; Homuth, G.* ; Mitchell, B.D.* ; Gudnason, V.* ; O'Donnell, C.J.* ; CARDIoGRAM Consortium (Meisinger, C. ; Wichmann, H.-E. ; Illig, T. ; Klopp, N.)

Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque.

Nat. Genet. 43, 940-947 (2011)
Publ. Version/Full Text Volltext DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Carotid intima media thickness (cIMT) and plaque determined by ultrasonography are established measures of subclinical atherosclerosis that each predicts future cardiovascular disease events. We conducted a meta-analysis of genome-wide association data in 31,211 participants of European ancestry from nine large studies in the setting of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. We then sought additional evidence to support our findings among 11,273 individuals using data from seven additional studies. In the combined meta-analysis, we identified three genomic regions associated with common carotid intima media thickness and two different regions associated with the presence of carotid plaque (P < 5 × 10(-8)). The associated SNPs mapped in or near genes related to cellular signaling, lipid metabolism and blood pressure homeostasis, and two of the regions were associated with coronary artery disease (P < 0.006) in the Coronary Artery Disease Genome-Wide Replication and Meta-Analysis (CARDIoGRAM) consortium. Our findings may provide new insight into pathways leading to subclinical atherosclerosis and subsequent cardiovascular events.
Altmetric
Additional Metrics?
[➜Log in]
Edit extra informations Login
Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords CORONARY-ARTERY-DISEASE; SINGLE NUCLEOTIDE POLYMORPHISMS; URIC-ACID LEVELS; HEART-DISEASE; MYOCARDIAL-INFARCTION; GENETIC-LOCI; LIPID-LEVELS; ATHEROSCLEROSIS; RISK; POPULATION
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Journal Nature Genetics
Quellenangaben Volume: 43, Issue: 10, Pages: 940-947 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
Research Unit Molecular Epidemiology (AME)
Institute of Genetic Epidemiology (IGE)