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Peitzsch, C.* ; Gorodetska, I.* ; Klusa, D.* ; Shi, Q.* ; Alves, T.C. ; Pantel, K.* ; Dubrovska, A.*

Metabolic regulation of prostate cancer heterogeneity and plasticity.

Semin. Cancer Biol. 82, 94-119 (2022)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Metabolic reprogramming is one of the main hallmarks of cancer cells. It refers to the metabolic adaptations of tumor cells in response to nutrient deficiency, microenvironmental insults, and anti-cancer therapies. Metabolic transformation during tumor development plays a critical role in the continued tumor growth and progression and is driven by a complex interplay between the tumor mutational landscape, epigenetic modifications, and microenvironmental influences. Understanding the tumor metabolic vulnerabilities might open novel diagnostic and therapeutic approaches with the potential to improve the efficacy of current tumor treatments. Prostate cancer is a highly heterogeneous disease harboring different mutations and tumor cell phenotypes. While the increase of intra-tumor genetic and epigenetic heterogeneity is associated with tumor progression, less is known about metabolic regulation of prostate cancer cell heterogeneity and plasticity. This review summarizes the central metabolic adaptations in prostate tumors, state-of-the-art technologies for metabolic analysis, and the perspectives for metabolic targeting and diagnostic implications.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Cancer Stem Cells ; Circulating Tumor Cells ; Disseminated Tumor Cells ; Metabolic Biomarkers ; Metabolic Heterogeneity ; Metabolic Reprogramming ; Metabolic Therapies ; Metabolomics ; Prostate Cancer
ISSN (print) / ISBN 1044-579X
e-ISSN 1096-3650
Journal Seminars in Cancer Biology
Quellenangaben Volume: 82, Issue: , Pages: 94-119 Article Number: , Supplement: ,
Publisher Saunders
Publishing Place Philadelphia, Pa.
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute for Pancreatic Beta Cell Research (IPI)