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Design of therapeutic vaccines: Hepatitis B as an example.
Microb. Biotechnol. 5, 270-282 (2012)
Therapeutic vaccines are currently developed for chronic viral infections, such as human papillomavirus (HPV), human immunodeficiency virus (HIV), herpesvirus and hepatitis B (HBV) and C (HCV) virus infections. As an alternative to antiviral treatment or to support only partially effective therapy a therapeutic vaccine shall activate the patient's immune system to fight and finally control or ideally even eliminate the virus. Whereas the success of prophylactic vaccination is based on rapid neutralization of the invading pathogen by antibodies, virus control and elimination of infected cells require T cells. Therefore, induction of a multi-specific and multifunctional T-cell response against key viral antigens is a paradigm of therapeutic vaccination - besides activation of a humoral immune response to limit virus spread. In this review, we describe options to develop a therapeutic vaccine for chronic viral infections using HBV as a promising example.
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Times Cited
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2.534
0.759
24
25
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
T-CELL RESPONSES; CHRONIC HBV INFECTION; TERM-FOLLOW-UP; VIRUS-INFECTION; SURFACE-ANTIGEN; IMMUNE-RESPONSE; CORE ANTIGEN; COMBINATION THERAPY; LYMPHOCYTE RESPONSE; GERMAN GUIDELINE
Language
english
Publication Year
2012
Prepublished in Year
2011
HGF-reported in Year
2011
ISSN (print) / ISBN
1751-7907
e-ISSN
1751-7915
Journal
Microbial Biotechnology
Quellenangaben
Volume: 5,
Issue: 2,
Pages: 270-282
Publisher
Wiley
Reviewing status
Peer reviewed
POF-Topic(s)
30203 - Molecular Targets and Therapies
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s)
Immune Response and Infection
PSP Element(s)
G-502700-003
G-520100-001
G-502700-004
G-501790-002
G-501790-001
G-501790-003
G-520100-001
G-502700-004
G-501790-002
G-501790-001
G-501790-003
PubMed ID
21958338
WOS ID
WOS:000300675900013
Erfassungsdatum
2011-11-28