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Lung organoids for hazard assessment of nanomaterials.
Int. J. Mol. Sci. 23:15666 (2022)
Lung epithelial organoids for the hazard assessment of inhaled nanomaterials offer a promising improvement to in vitro culture systems used so far. Organoids grow in three-dimensional (3D) spheres and can be derived from either induced pluripotent stem cells (iPSC) or primary lung tissue stem cells from either human or mouse. In this perspective we will highlight advantages and disadvantages of traditional culture systems frequently used for testing nanomaterials and compare them to lung epithelial organoids. We also discuss the differences between tissue and iPSC-derived organoids and give an outlook in which direction the whole field could possibly go with these versatile tools.
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Publication type
Article: Journal article
Document type
Review
Keywords
3d In Vitro Models ; Hazard Assessment ; Nanomaterial ; Organoids ; Pluripotent Stem Cells ; Pulmonary Particle Exposure ; Respiratory Toxicity; Pluripotent Stem-cells; Alveolar Epithelial-cells; In-vitro; Inflammatory Responses; Carbon Nanotubes; Toxicity; Models; Differentiation; Nanoparticles; Induction
ISSN (print) / ISBN
1422-0067
e-ISSN
1661-6596
Quellenangaben
Volume: 23,
Issue: 24,
Article Number: 15666
Publisher
MDPI
Publishing Place
Basel
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Lung Health and Immunity (LHI)
Grants
European Union’s Horizon 2020