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Kastlmeier, M.T. ; Günther, E. ; Stöger, T. ; Voss, C.

Lung organoids for hazard assessment of nanomaterials.

Int. J. Mol. Sci. 23:15666 (2022)
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Lung epithelial organoids for the hazard assessment of inhaled nanomaterials offer a promising improvement to in vitro culture systems used so far. Organoids grow in three-dimensional (3D) spheres and can be derived from either induced pluripotent stem cells (iPSC) or primary lung tissue stem cells from either human or mouse. In this perspective we will highlight advantages and disadvantages of traditional culture systems frequently used for testing nanomaterials and compare them to lung epithelial organoids. We also discuss the differences between tissue and iPSC-derived organoids and give an outlook in which direction the whole field could possibly go with these versatile tools.
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Publication type Article: Journal article
Document type Review
Keywords 3d In Vitro Models ; Hazard Assessment ; Nanomaterial ; Organoids ; Pluripotent Stem Cells ; Pulmonary Particle Exposure ; Respiratory Toxicity; Pluripotent Stem-cells; Alveolar Epithelial-cells; In-vitro; Inflammatory Responses; Carbon Nanotubes; Toxicity; Models; Differentiation; Nanoparticles; Induction
Language english
Publication Year 2022
HGF-reported in Year 2022
ISSN (print) / ISBN 1661-6596
e-ISSN 1422-0067
Journal International Journal of Molecular Sciences
Quellenangaben Volume: 23, Issue: 24, Pages: , Article Number: 15666 Supplement: ,
Publisher MDPI
Publishing Place Basel
Reviewing status Peer reviewed
Institute(s) Institute of Lung Health and Immunity (LHI)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Lung Research
PSP Element(s) G-505000-001
Grants European Union’s Horizon 2020
DOI 10.3390/ijms232415666
WOS ID 000901020600001
WOS ID WOS:000901020600001
Scopus ID 85144493007
PubMed ID 36555307
Erfassungsdatum 2023-01-12
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