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Hellbach, F.* ; Sinke, L.* ; Costeira, R.* ; Baumeister, S.E.* ; Beekman, M.* ; Louca, P.* ; Leeming, E.R.* ; Mompeo, O.* ; Berry, S.* ; Wilson, R. ; Wawro, N. ; Freuer, D.* ; Hauner, H.* ; Peters, A. ; Winkelmann, J. ; Koenig, W.* ; Meisinger, C.* ; Waldenberger, M. ; Heijmans, B.T.* ; Slagboom, P.E.* ; Bell, J.T.* ; Linseisen, J.*

Pooled analysis of epigenome-wide association studies of food consumption in KORA, TwinsUK and LLS.

Eur. J. Nutr. 62, 1357-1375 (2022)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Purpose: Examining epigenetic patterns is a crucial step in identifying molecular changes of disease pathophysiology, with DNA methylation as the most accessible epigenetic measure. Diet is suggested to affect metabolism and health via epigenetic modifications. Thus, our aim was to explore the association between food consumption and DNA methylation. Methods: Epigenome-wide association studies were conducted in three cohorts: KORA FF4, TwinsUK, and Leiden Longevity Study, and 37 dietary exposures were evaluated. Food group definition was harmonized across the three cohorts. DNA methylation was measured using Infinium MethylationEPIC BeadChip in KORA and Infinium HumanMethylation450 BeadChip in the Leiden study and the TwinsUK study. Overall, data from 2293 middle-aged men and women were included. A fixed-effects meta-analysis pooled study-specific estimates. The significance threshold was set at 0.05 for false-discovery rate-adjusted p values per food group. Results: We identified significant associations between the methylation level of CpG sites and the consumption of onions and garlic (2), nuts and seeds (18), milk (1), cream (11), plant oils (4), butter (13), and alcoholic beverages (27). The signals targeted genes of metabolic health relevance, for example, GLI1, RPTOR, and DIO1, among others. Conclusion: This EWAS is unique with its focus on food groups that are part of a Western diet. Significant findings were mostly related to food groups with a high-fat content.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Diet ; Ewas ; Food Group ; High-fat Foods ; Humans; Dna Methylation; Nonagenarian Siblings; Risk; Diet; Identification; Vitamin-b-12; Folate; Blood
ISSN (print) / ISBN 1436-6207
e-ISSN 1436-6215
Journal European Journal of Nutrition
Quellenangaben Volume: 62, Issue: 3, Pages: 1357-1375 Article Number: , Supplement: ,
Publisher Springer
Publishing Place Heidelberg
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology II (EPI2)
Institute of Neurogenomics (ING)
Grants iMED
Helmholtz Association, Germany
Helmholtz Zentrum Munchen-German Research Center for Environmental Health - BMBF
State of Bavaria
Munich Center of Health Sciences (MC-Health)
Ludwig-Maximilians-Universitat, LMUinnovativ
European HDHL Joint Programming Initiative funding scheme
Joint Programming Initiative a Healthy Diet for a Healthy Life' (JPI-HDHL) DIMENSION project
European Union
Innovation-Oriented Research Program on Genomics
Centre for Medical Systems Biology
Netherlands Consortium for Healthy Ageing
Netherlands Genomics Initiative, Netherlands Organization for Scientific Research (NWO)
Projekt DEAL
BBMRI-NL
Dutch government
Wellcome Trust
Medical Research Council
Versus Arthritis
European Union Horizon 2020
Chronic Disease Research Foundation (CDRF)
Zoe Global Ltd
National Institute for Health Research (NIHR) Clinical Research Network (CRN) and Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust
King's College London
European HDHL Joint Programming Initiative funding scheme DIMENSION project (BBSRC)
Unilever Colworth