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What's new in the molecular mechanisms of diabetic kidney disease: Recent advances.
Int. J. Mol. Sci. 24:570 (2023)
Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease, including end-stage kidney disease, and increases the risk of cardiovascular mortality. Although the treatment options for DKD, including angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, sodium-glucose cotransporter 2 inhibitors, and mineralocorticoid receptor antagonists, have advanced, their efficacy is still limited. Thus, a deeper understanding of the molecular mechanisms of DKD onset and progression is necessary for the development of new and innovative treatments for DKD. The complex pathogenesis of DKD includes various different pathways, and the mechanisms of DKD can be broadly classified into inflammatory, fibrotic, metabolic, and hemodynamic factors. Here, we summarize the recent findings in basic research, focusing on each factor and recent advances in the treatment of DKD. Collective evidence from basic and clinical research studies is helpful for understanding the definitive mechanisms of DKD and their regulatory systems. Further comprehensive exploration is warranted to advance our knowledge of the pathogenesis of DKD and establish novel treatments and preventive strategies.
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Publication type
Article: Journal article
Document type
Review
Keywords
Sglt2 Inhibitor ; Diabetic Kidney Disease ; Fibrosis ; Hemodynamics ; Inflammation ; Metabolism; Glycation End-products; Mineralocorticoid Receptor Antagonists; Cotransporter 2 Inhibitors; Growth-factor-beta; Glomerular Hyperfiltration; Renal-insufficiency; Sglt2 Inhibitors; Clinical-trial; Double-blind; Activation
ISSN (print) / ISBN
1422-0067
e-ISSN
1661-6596
Quellenangaben
Volume: 24,
Issue: 1,
Article Number: 570
Publisher
MDPI
Publishing Place
Basel
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Metabolism and Cell Death (MCD)
Grants
JSPS KAKENHI
JSPS KAKENHI