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Chamorro, R.* ; Jouffe, C. ; Oster, H.* ; Uhlenhaut, N.H. ; Meyhöfer, S.M.*

When should I eat: A circadian view on food intake and metabolic regulation.

Acta Physiol. 237:e13936 (2023)
DOI PMC
Creative Commons Lizenzvertrag
Open Access Green as soon as Postprint is submitted to ZB.
The circadian clock is a hierarchical timing system regulating most physiological and behavioral functions with a period of approximately 24 hours in humans and other mammalian species. The circadian clock drives daily eating rhythms that, in turn, reinforce the circadian clock network itself to anticipate and orchestrate metabolic responses to food intake. Eating is tightly interconnected with the circadian clock and recent evidence shows that the timing of meals is crucial for the control of appetite and metabolic regulation. Obesity results from combined long-term dysregulation in food intake (homeostatic and hedonic circuits), energy expenditure, and energy storage. Increasing evidence supports that the loss of synchrony of daily rhythms significantly impairs metabolic homeostasis and is associated with obesity. This review presents an overview of mechanisms regulating food intake (homeostatic/hedonic) and focuses on the crucial role of the circadian clock on the metabolic response to eating, thus providing a fundamental research axis to maintain a healthy eating behavior.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Circadian Misalignment ; Homeostatic/hedonic Food Intake ; Mammalian Circadian Clock ; Metabolism ; Obesity; Randomized Controlled-trial; Fasting Lipid Profiles; Meal Frequency; Gene-expression; Caloric-intake; Weight-loss; Glucocorticoid-receptor; Anticipatory Activity; Macronutrient Intake; Insulin Sensitivity
ISSN (print) / ISBN 1748-1708
e-ISSN 1748-1716
Journal Acta Physiologica
Quellenangaben Volume: 237, Issue: 3, Pages: , Article Number: e13936 Supplement: ,
Publisher Wiley
Publishing Place Hoboken
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Endocrinology (IDE)
Institute of Diabetes and Cancer (IDC)