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Studies on patients with atopic diseases at the Environmental Research Station Schneefernerhaus (UFS).
In: Science at the environmental research station Schneefernerhaus/Zugspitze. 2022. 37-52
Mountain climate therapy takes advantage of specific climatic conditions to treat chronic allergic diseases. The aim of the study was to investigate effects of a 5-day observation period on atopic diseases at the Environmental Research Station Schneefernerhaus (UFS; Umweltforschungsstation). 18 patients with grass pollen-induced rhinoconjunctivitis, atopic ezcema or asthma and 11 non-allergic controls were included in this study. Skin physiology parameters, changes of the respiratory and nasal functions, subjective symptoms and blood parameters were measured during a 5-day observation period in the Environmental Research Station Schneefernerhaus at the moderate altitude mountain region (Zugspitze; 2650 m alt.) compared to a low altitude area (Munich; 519 m alt.).
Histamine induced itch decreased significantly. Several of the skin physiology parameters
changed significantly during the observation period (decrease of skin hydration, increase of skin smoothness, skin roughness, skin scaliness and pH-value). In patients with atopic eczema, the SCORAD (Severity Scoring of Atopic Dermatitis) and the scores of the DIELH (Deutsches Instrument zur Erfassung der Lebensqualität bei Hauterkrankungen) did not change significantly. Parameters of nasal function (rhinomanometry, eosinophil cationic protein (ECP) in nasal secretions) did not change significantly. The vital capacity (VC) decreased significantly, several other parameters of lung function (FEV1/VC, PEF, MEF 50, MMFEF 25/75) showed a slight, but statistically significant improvement. ECP (eosinophil cationic protein) and IL-33 in the serum and parameters of blood count changed significantly. In dependence on the atopic disease the benefit of a moderate altitude mountain climate sojourn over a period of 5 days differed – especially itching of the skin and asthma parameters improved. Assessing the parameters during a longer observation periods in alpine climate would be useful. The methodology used can serve as a suitable template for qualified studies on the effect of climate therapy.
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Publication type
Article: Edited volume or book chapter
Keywords
mountain climate therapy, atopic diseases, atopic eczema, asthma, rhinoconjunctivitis allergica, skin physiology parameters, rhinomanometry, parameters of lung function,
Umweltforschungsstation Schneefernerhaus, Zugspitze
Book Volume Title
Science at the environmental research station Schneefernerhaus/Zugspitze
Quellenangaben
Pages: 37-52
Non-patent literature
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Institute(s)
Institute for Allergy Research (IAF)