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Vogel von Falckenstein, J.* ; Freuer, D.* ; Peters, A. ; Heier, M. ; Linseisen, J.* ; Meisinger, C.*

Sex-specific associations between systolic, diastolic and pulse pressure and hemostatic parameters in the population-based KORA-Fit study: A cross-sectional study.

Thromb. J. 21:7 (2023)

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	Open Access Gold

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BACKGROUND: Several prior studies postulated an effect of hypertension on coagulation factors. However, population-based studies investigating the sex-specific associations between hypertension and hemostatic parameters are scarce. Therefore, we investigated the relationship between blood pressure and parameters of coagulation, namely activated partial thromboplastin time (aPTT), international normalized ratio (INR), fibrinogen, factor VIII, antithrombin III, protein C, protein S, and D-dimer in men and women from the general population. METHODS: Based on 803 participants (376 men, 427 women) from the KORA-Fit Study the sex-specific relationship between systolic, diastolic, and pulse pressure and commonly measured coagulation factors were investigated using multivariable-adjusted linear regression models. RESULTS: Hypertensive males had significantly higher median fibrinogen levels and factor VIII activity in comparison to normotensive males. There was a statistically significant difference between females with and without hypertension regarding the parameter fibrinogen, D-dimers, Protein S activity, and factor VIII activity. In multivariable linear regression analyses no significant association between systolic blood pressure, diastolic blood pressure, as well as pulse pressure and the investigated hemostatic parameters was found in men. In women, a significant positive association could be observed between systolic blood pressure and D-dimer level [β-estimate per mmHg increase 3.37 (95% CI 0.935-5.804; p = 0.007)] and between pulse pressure and D-dimer level [β-estimate per mmHg increase 5.351 (95% CI 1.772-8.930; p = 0.003)]. CONCLUSIONS: It appears that sex differences exist in the association between blood pressure parameters and commonly measured coagulation markers in the general population. Further studies are needed to identify the underlying causes.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Blood Pressure ; Coagulation ; General Population ; Hypertension ; Kora Study; Cardiovascular Risk-factors; Blood-pressure; Coagulation-factors; D-dimer; Plasma-fibrinogen; Physical-activity; Factor-viii; Hypertension; Disease; Determinants

ISSN (print) / ISBN 1477-9560

e-ISSN 1477-9560

Journal Thrombosis Journal

Quellenangaben Volume: 21, Issue: 1, Article Number: 7

Publisher BMC

Publishing Place Campus, 4 Crinan St, London N1 9xw, England

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Epidemiology II (EPI2)

Grants Munich Center of Health Sciences (MC-Health), Ludwig-Maximilians-Universitaet, as part of LMUinnovativ
State of Bavaria
German Federal Ministry of Education and Research (BMBF)