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Huemer, M.-T. ; Kluttig, A.* ; Fischer, B.* ; Ahrens, W.* ; Castell, S.* ; Ebert, N.* ; Gastell, S.* ; Jöckel, K.H.* ; Kaaks, R.* ; Karch, A.* ; Keil, T.* ; Kemmling, Y.* ; Krist, L.* ; Leitzmann, M.* ; Lieb, W.* ; Meinke-Franze, C.* ; Michels, K.B.* ; Mikolajczyk, R.* ; Moreno Velásquez, I.* ; Pischon, T.* ; Schipf, S.* ; Schmidt, B.* ; Schöttker, B.* ; Schulze, M.B.* ; Stocker, H.* ; Teismann, H.* ; Wirkner, K.* ; Drey, M.* ; Peters, A. ; Thorand, B.

Grip strength values and cut-off points based on over 200,000 adults of the German National Cohort - a comparison to the EWGSOP2 cut-off points.

Age Ageing 52:10 (2023)
Postprint DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
BACKGROUND: The European Working Group on Sarcopenia in Older People (EWGSOP) updated in 2018 the cut-off points for low grip strength to assess sarcopenia based on pooled data from 12 British studies. OBJECTIVE: Comparison of the EWGSOP2 cut-off points for low grip strength to those derived from a large German sample. METHODS: We assessed the grip strength distribution across age and derived low grip strength cut-off points for men and women (peak mean -2.5 × SD) based on 200,389 German National Cohort (NAKO) participants aged 19-75 years. In 1,012 Cooperative Health Research in the Region of Augsburg (KORA)-Age participants aged 65-93 years, we calculated the age-standardised prevalence of low grip strength and time-dependent sensitivity and specificity for all-cause mortality. RESULTS: Grip strength increased in the third and fourth decade of life and declined afterwards. Calculated cut-off points for low grip strength were 29 kg for men and 18 kg for women. In KORA-Age, the age-standardised prevalence of low grip strength was 1.5× higher for NAKO-derived (17.7%) compared to EWGSOP2 (11.7%) cut-off points. NAKO-derived cut-off points yielded a higher sensitivity and lower specificity for all-cause mortality. CONCLUSIONS: Cut-off points for low grip strength from German population-based data were 2 kg higher than the EWGSOP2 cut-off points. Higher cut-off points increase the sensitivity, thereby suggesting an intervention for more patients at risk, while other individuals might receive additional diagnostics/treatment without the urgent need. Research on the effectiveness of intervention in patients with low grip strength defined by different cut-off points is needed.
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Publication type Article: Journal article
Document type Scientific Article
Keywords European Working Group On Sarcopenia In Older People (ewgsop) ; Cut-off Points ; Grip Strength ; Mortality ; Probable Sarcopenia; Handgrip Strength; Quality-assurance; Normative Data; Age; Mobility; Fitness
Language english
Publication Year 2023
HGF-reported in Year 2023
ISSN (print) / ISBN 0002-0729
e-ISSN 1468-2834
Journal Age and Ageing
Quellenangaben Volume: 52, Issue: 1, Pages: , Article Number: 10 Supplement: ,
Publisher Oxford University Press
Publishing Place Great Clarendon St, Oxford Ox2 6dp, England
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504000-002
G-504090-001
G-504000-010
DOI 10.1093/ageing/afac324
WOS ID 000923090400004
Scopus ID 85159748216
PubMed ID 36702514
Erfassungsdatum 2023-02-01
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