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Fasoula, N.-A. ; Karlas, A. ; Prokopchuk, O.* ; Katsouli, N. ; Bariotakis, M. ; Liapis, E. ; Götz, A. ; Kallmayer, M.* ; Reber, J. ; Novotny, A.* ; Friess, H.* ; Ringelhan, M.* ; Schmid, R.* ; Eckstein, H.H.* ; Hofmann, S.M. ; Ntziachristos, V.

Non-invasive multispectral optoacoustic tomography resolves intrahepatic lipids in patients with hepatic steatosis.

Photoacoustics 29:100454 (2023)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Hepatic steatosis is characterized by intrahepatic lipid accumulation and may lead to irreversible liver damage if untreated. Here, we investigate whether multispectral optoacoustic tomography (MSOT) can offer label-free detection of liver lipid content to enable non-invasive characterization of hepatic steatosis by analyzing the spectral region around 930 nm, where lipids characteristically absorb. In a pilot study, we apply MSOT to measure liver and surrounding tissues in five patients with liver steatosis and five healthy volunteers, revealing significantly higher absorptions at 930 nm in the patients, while no significant difference was observed in the subcutaneous adipose tissue of the two groups. We further corroborated the human observations with corresponding MSOT measurements in high fat diet (HFD) - and regular chow diet (CD)-fed mice. This study introduces MSOT as a potential non-invasive and portable technique for detecting/monitoring hepatic steatosis in clinical settings, providing justification for larger studies.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Lipid Imaging ; Metabolism ; Molecular Imaging ; Msot ; Nafld ; Non-alcoholic Fatty Liver Disease ; Photoacoustics; Fatty Liver-disease; Diagnosis; Biopsy; Association
ISSN (print) / ISBN 2213-5979
Journal Photoacoustics
Quellenangaben Volume: 29, Issue: , Pages: , Article Number: 100454 Supplement: ,
Publisher Elsevier
Publishing Place Hackerbrucke 6, 80335 Munich, Germany
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)
Institute of Diabetes and Regeneration Research (IDR)
Grants German Center of Infection Research (DZIF)
Helmholtz Zentrum Muenchen
DZHK (German Centre for Cardiovascular Research)
European Research Council (ERC)