PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Stefan, N. ; Schick, F. ; Birkenfeld, A.L. ; Häring, H.-U. ; White, M.F.*

The role of hepatokines in NAFLD.

Cell Metab. 35, 236-252 (2023)
Publ. Version/Full Text Postprint DOI PMC
Open Access Green
Non-alcoholic fatty liver disease (NAFLD) is not only a consequence of insulin resistance, but it is also an important cause of insulin resistance and major non-communicable diseases (NCDs). The close relationship of NAFLD with visceral obesity obscures the role of fatty liver from visceral adiposity as the main pathomechanism of insulin resistance and NCDs. To overcome this limitation, in analogy to the concept of adipokines, in 2008 we introduced the term hepatokines to describe the role of fetuin-A in metabolism. Since then, several other hepatokines were tested for their effects on metabolism. Here we address the dysregulation of hepatokines in people with NAFLD. Then, we discuss pathophysiological mechanisms of cardiometabolic diseases specifically related to NAFLD by focusing on hepatokine-related organ crosstalk. Finally, we propose how the determination of major hepatokines and adipokines can be used for pathomechanism-based clustering of insulin resistance in NAFLD and visceral obesity to better implement precision medicine in clinical practice.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Altmetric
29.000
5.096
38
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Review
Keywords Hormone-binding Globulin; Fatty Liver-disease; Fetuin-a Levels; Alpha(2)-heremans-schmid Glycoprotein/fetuin-a; Incident Diabetes-mellitus; De-novo Lipogenesis; Insulin-resistance; Hepatic Steatosis; Selenoprotein P; Adipose-tissue
Language english
Publication Year 2023
HGF-reported in Year 2023
ISSN (print) / ISBN 1550-4131
e-ISSN 1932-7420
Journal Cell Metabolism
Quellenangaben Volume: 35, Issue: 2, Pages: 236-252 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)
POF-Topic(s) 90000 - German Center for Diabetes Research
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502400-001
Grants National Institutes of Health
German Federal Ministry of Education and Research (BMBF)
DOI 10.1016/j.cmet.2023.01.006
WOS ID 000935150200001
Scopus ID 85147336851
PubMed ID 36754018
Erfassungsdatum 2023-02-11
[➜Report correction]