PuSH - Publication Server of Helmholtz Zentrum München: A unified classification approach rating clinical utility of protein biomarkers across neurologic diseases.

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... Journal

... Publication Type

... Research Data

... Publication Year

Publication overview

Support & Contact

Contact persons

Help

Data protection

Bernhardt, A.M.* ; Tiedt, S.* ; Teupser, D.* ; Dichgans, M.* ; Meyer, B.* ; Gempt, J.* ; Kuhn, P.H.* ; Simons, M.* ; Palleis, C.* ; Weidinger, E.* ; Nübling, G.* ; Holdt, L.* ; Hönikl, L.* ; Gasperi, C.* ; Giesbertz, P.* ; Müller, S.A.* ; Breimann, S.* ; Lichtenthaler, S.F.* ; Kuster, B.* ; Mann, M.* ; Imhof, A.* ; Barth, T.* ; Hauck, S.M. ; Zetterberg, H.* ; Otto, M.* ; Weichert, W.* ; Hemmer, B.* ; Levin, J.*

A unified classification approach rating clinical utility of protein biomarkers across neurologic diseases.

EBioMedicine 89:104456 (2023)

Publ. Version/Full Text

DOI

PMC

	Open Access Gold

Abstract
Metrics
Extra information

A major evolution from purely clinical diagnoses to biomarker supported clinical diagnosing has been occurring over the past years in neurology. High-throughput methods, such as next-generation sequencing and mass spectrometry-based proteomics along with improved neuroimaging methods, are accelerating this development. This calls for a consensus framework that is broadly applicable and provides a spot-on overview of the clinical validity of novel biomarkers. We propose a harmonized terminology and a uniform concept that stratifies biomarkers according to clinical context of use and evidence levels, adapted from existing frameworks in oncology with a strong focus on (epi)genetic markers and treatment context. We demonstrate that this framework allows for a consistent assessment of clinical validity across disease entities and that sufficient evidence for many clinical applications of protein biomarkers is lacking. Our framework may help to identify promising biomarker candidates and classify their applications by clinical context, aiming for routine clinical use of (protein) biomarkers in neurology.

Altmetric

Additional Metrics?

[➜Log in]

Edit extra informations Login

Publication type Article: Journal article

Document type Review

Corresponding Author

Keywords Analytical Validity ; Biomarker ; Clinical Utility ; Neurology ; Protein ; Proteomics; Fibrillary Acidic Protein; Alzheimers-disease; Cerebrospinal-fluid; Multiple-sclerosis; Alpha-synuclein; Neurofilament Light; Serum Biomarkers; Diagnosis; Csf; Marker

ISSN (print) / ISBN 2352-3964

e-ISSN 2352-3964

Journal EBioMedicine

Quellenangaben Volume: 89, Article Number: 104456

Publisher Elsevier

Publishing Place Amsterdam [u.a.]

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) CF Metabolomics & Proteomics (CF-MPC)

Grants Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)
Munich Cluster for Systems Neurology
BMBF