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Grychtol, R.* ; Riemann, L.* ; Gaedcke, S.* ; Liu, B.* ; Deluca, D.* ; Forster, R.* ; Maison, N. ; Thiele, D.* ; Jakobs, N.* ; Bahmer, T.* ; Meyer, M.* ; Foth, S.* ; Weber, S.* ; Rietschel, E.* ; Rabe, K.F.* ; Kopp, M.V.* ; von Mutius, E. ; Dittrich, A.M.* ; Hansen, G.* ; ALLIANCE Study Group (Illi, S. ; Marzi, C. ; Zissler, U.M. ; Schmidt-Weber, C.B.)

Validation of the Asthma Severity Scoring System (ASSESS) in the ALLIANCE cohort.

J. Allergy Clin. Immunol. 151, 1525-1535.e4 (2023)
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BACKGROUND: The Asthma Severity Scoring System (ASSESS) quantifies asthma severity in adolescents and adults. Scale performance in children < 12 years is unknown. OBJECTIVE: To validate the ASSESS score in the All Age Asthma Cohort (ALLIANCE) and explore its use in children <12 years. METHODS: Scale properties, responsiveness, and known-group validity were assessed in 247 children (median age 11 years, IQR: 8-13 years) and 206 adults (median age 52 years, IQR: 43-63 years). RESULTS: Overall, measures of internal test consistency and test-retest reliability were similar to the original data of the Severe Asthma Research Program (SARP). Cronbach's α was 0.59 in children 12-18 years and 0.73 in adults, reflecting the inclusion of multiple and not always congruent dimensions to the ASSESS score especially in children. Analysis of known-group validity confirmed the discriminatory power, as the ASSESS score was significantly worse in patients with poor asthma control, exacerbations and increased salbutamol use. In children between 6-11 years test reliability was inferior compared to adults and adolescents (Cronbach's α 0.27) mostly due to a less lung function impairment in asthmatic children of this age group. Known-group validity however confirmed good discriminative power regarding severity-associated variables similar to adolescents and adults. CONCLUSION: Test reliability and validity of the ASSESS score was confirmed in the ALLIANCE cohort. In children aged 6-11 years internal consistency was inferior compared to older asthma patients, however test validity was good and encourages age-spanning usage of the ASSESS score in all asthma patients ≥ 6 years.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Alliance ; Adult Asthma ; Asthma ; Asthma Control ; Asthma Severity ; Children ; Pediatric Asthma ; Validation Study; Lung-function; Children; Spirometry; Classification; Symptoms; Mismatch; Values
Language english
Publication Year 2023
HGF-reported in Year 2023
ISSN (print) / ISBN 0091-6749
e-ISSN 1097-6825
Journal The journal of allergy and clinical immunology
Quellenangaben Volume: 151, Issue: 6, Pages: 1525-1535.e4 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Amsterdam [u.a.]
Reviewing status Peer reviewed
Institute(s) Institute of Asthma and Allergy Prevention (IAP)
Institute for Allergy Research (IAF)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Allergy
PSP Element(s) G-503300-001
G-505400-001
Grants TITUS (The First Thousand Days of Life) Clinician Scientist Program - Else Kroner-Fresenius-Stiftung
Dorenkamp Foundation
Cluster of Excellence RESIST (DFG, German Research Foundation)
German Federal Ministry of Education and Research as part of the German Center for Lung Research funding
DOI 10.1016/j.jaci.2023.01.027
WOS ID 001018654100001
Scopus ID 85160079482
PubMed ID 36804993
Erfassungsdatum 2023-02-23
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