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Functionally defined substates within the human embryonic stem cell compartment.
Stem Cell Res. 7, 145-153 (2011)
Human embryonic stem (ES) cells can undergo spontaneously differentiation in standard culture conditions, demonstrating that the undifferentiated state is relatively unstable. The heterogeneous expression of SSEA3 observed within human ES colonies, provides a means to examine undifferentiated stem cell substates. Through functional testing of single cells we have shown that undifferentiated ES cells can be segregated into functionally discrete subpopulations on the basis of SSEA3 expression: SSEA3(High), SSEA(Low) and SSEA3(Negative). Human ES subpopulations were found to be interconvertible, but they possess distinct properties when challenged to differentiate along the neural lineage. These data suggest that ES cells with pluripotent/self-renewal capacities can exhibit different responses to induction of differentiation.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
differentiation antigens; lineage choice; culture; pluripotency; surface; heterogeneity; ssea-4
ISSN (print) / ISBN
1873-5061
e-ISSN
1876-7753
Journal
Stem Cell Research
Quellenangaben
Volume: 7,
Issue: 2,
Pages: 145-153
Publisher
Elsevier
Publishing Place
Kidlington, Oxford
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Research Unit Stem Cell Dynamics (SCD)