PuSH - Publication Server of Helmholtz Zentrum München: Processing of carbon-reinforced construction materials releases PM<sub>2.5</sub> inducing inflammation and (secondary) genotoxicity in human lung epithelial cells and fibroblasts.

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Pantzke, J. ; Koch, A.* ; Zimmermann, E. ; Rastak, N. ; Offer, S. ; Bisig, B. ; Bauer, S. ; Oeder, S. ; Orasche, J. ; Fiala, P.* ; Stintz, M.* ; Rüger, C.* ; Streibel, T.* ; Di Bucchianico, S. ; Zimmermann, R.

Processing of carbon-reinforced construction materials releases PM_2.5 inducing inflammation and (secondary) genotoxicity in human lung epithelial cells and fibroblasts.

Environ. Toxicol. Pharmacol. 98:104079 (2023)

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Open Access Green as soon as Postprint is submitted to ZB.

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Building demolition following domestic fires or abrasive processing after thermal recycling can release particles harmful for the environment and human health. To mimic such situations, particles release during dry-cutting of construction materials was investigated. A reinforcement material consisting of carbon rods (CR), carbon concrete composite (C³) and thermally treated C³ (ttC³) were physicochemically and toxicologically analyzed in monocultured lung epithelial cells, and co-cultured lung epithelial cells and fibroblasts at the air-liquid interface. C³ particles reduced their diameter to WHO fibre dimensions during thermal treatment. Caused by physical properties or by polycyclic aromatic hydrocarbons and bisphenol A found in the materials, especially the released particles of CR and ttC³ induced an acute inflammatory response and (secondary) DNA damage. Transcriptome analysis indicated that CR and ttC³ particles carried out their toxicity via different mechanisms. While ttC³ affected pro-fibrotic pathways, CR was mostly involved in DNA damage response and in pro-oncogenic signaling.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Air-liquid Interface ; Bisphenol A ; Carbon Fibre Toxicity ; Polycyclic Aromatic Hydrocarbons ; Transcriptome; Oxidative Stress; Bisphenol-a; Dna-damage; Exposure; Metabolism; Toxicity; Power; Pahs

ISSN (print) / ISBN 1382-6689

e-ISSN 1872-7077

Journal Environmental Toxicology and Pharmacology

Quellenangaben Volume: 98, Article Number: 104079

Publisher Elsevier

Publishing Place Radarweg 29, 1043 Nx Amsterdam, Netherlands

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Cooperation Group Comprehensive Molecular Analytics (CMA)

Grants European Union (European Fund for regional development) via the Technologie-Beratungs-Institut GmbH (TBI, Technology Consulting Institute of the Ministry of Economic Affairs, Infrastructure, Tourism and Labor Mecklenburg-Western Pomerania)
Research in the loan program "Zwan-zig20-Partnerschaft fur Innovation"
German Federal Ministry of Education and Research

PuSH - Publication Server of Helmholtz Zentrum München

Processing of carbon-reinforced construction materials releases PM2.5 inducing inflammation and (secondary) genotoxicity in human lung epithelial cells and fibroblasts.

Processing of carbon-reinforced construction materials releases PM_2.5 inducing inflammation and (secondary) genotoxicity in human lung epithelial cells and fibroblasts.