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Bhatia, H.S. ; Apweiler, M.* ; Sun, L.* ; Baron, J.* ; Tirkey, A.* ; Fiebich, B.L.*

Licochalcone A inhibits prostaglandin E2 by targeting the MAPK pathway in LPS activated primary microglia.

Molecules 28:17 (2023)
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Neuroinflammation and oxidative stress are conditions leading to neurological and neuropsychiatric disorders. Natural compounds exerting anti-inflammatory and anti-oxidative effects, such as Licochalcone A, a bioactive flavonoid present in a traditional Chinese herb (licorice), might be beneficial for the treatment of those disorders. Therefore, this study aimed to investigate the anti-inflammatory and anti-oxidative effects of Licochalcone A in LPS-activated primary rat microglia. Licochalcone A dose-dependently prevented LPS-induced PGE2 release by inhibiting the arachidonic acid (AA)/cylcooxygenase (COX) pathway decreasing phospholipase A2, COX-1, and COX-2 protein levels. Furthermore, LPS-induced levels of the cytokines IL-6 and TNFα were reduced by Licochalcone A, which also inhibited the phosphorylation and, thus, activation of the mitogen-activated protein kinases (MAPK) p38 MAPK and Erk 1/2. With the reduction of 8-iso-PGF2α, a sensitive marker for oxidative stress, anti-oxidative effects of Licochalcone A were demonstrated. Our data demonstrate that Licochalcone A can affect microglial activation by interfering in important inflammatory pathways. These in vitro findings further demonstrate the potential value of Licochalcone A as a therapeutic option for the prevention of microglial dysfunction related to neuroinflammatory diseases. Future research should continue to investigate the effects of Licochalcone A in different disease models with a focus on its anti-oxidative and anti-neuroinflammatory properties.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords 8-iso-pgf2α ; Cox-2 ; Glycyrrhiza Glabra ; Licochalcone A ; Pge2 ; Arachidonic Acid ; Flavonoids ; Neuroinflammation ; Oxidative Stress; Nf-kappa-b; Alzheimers-disease; Acetylsalicylic-acid; Oxidative Stress; Expression; Neuroinflammation; Cyclooxygenase-2; Cox-2; Release; Cpla(2)
ISSN (print) / ISBN 1420-3049
e-ISSN 1420-3049
Journal Molecules
Quellenangaben Volume: 28, Issue: 4, Pages: , Article Number: 17 Supplement: ,
Publisher MDPI
Publishing Place Basel
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute for Tissue Engineering and Regenerative Medicine (ITERM)
Grants Alzheimer Forschung Initiative e.V. (AFI)