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Molder, J.* ; Guiu-Jurado, E.* ; Moulla, Y.* ; Stroh, C.* ; Dietrich, A.* ; Schön, M.R.* ; Gärtner, D.* ; Lohmann, T.* ; Dressler, M.* ; Stumvoll, M. ; Kovacs, P.* ; Blüher, M. ; Klöting, N.

Sex-specific effects of the genetic variant rs10487505 upstream of leptin in the development of obesity.

Genes 14:11 (2023)
DOI PMC
Creative Commons Lizenzvertrag
Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
The SNP rs10487505 in the promotor region of the leptin gene was reported to be associated with decreased circulating leptin and increased body mass index (BMI). However, the phenotypic outcomes affected by rs10487505 in the leptin regulatory pathway have not been systematically studied. Therefore, the aim of this study was to elucidate the influence of rs10487505 on leptin mRNA expression and obesity-related parameters. We genotyped rs10487505 in DNA samples from 1665 patients with obesity and lean controls and measured leptin gene expression in paired samples of adipose tissue (AT, N = 310), as well as circulating leptin levels. We confirm the leptin-lowering effect of rs10487505 in women. In contrast to the previously reported data from population-based studies, in this mainly obese cohort, we describe a lower mean BMI in women carrying the C allele of rs10487505. However, no association of rs10487505 with AT leptin mRNA expression was found. Our data suggest that reduced circulating leptin levels are not a result of the direct silencing of leptin mRNA expression. Furthermore, leptin reduction by rs10487505 does not associate with BMI in a linear manner. Instead, the decreasing effect on BMI might be dependent on the severity of obesity.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Adipose Tissue ; Leptin ; Obesity ; Rs10487505; Plasma Leptin; Mechanisms; Rna
ISSN (print) / ISBN 2073-4425
e-ISSN 2073-4425
Journal Genes
Quellenangaben Volume: 14, Issue: 2, Pages: , Article Number: 11 Supplement: ,
Publisher MDPI
Publishing Place St Alban-anlage 66, Ch-4052 Basel, Switzerland
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)