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Amponsah-Offeh, M.* ; Diaba-Nuhoho, P.* ; Speier, S. ; Morawietz, H.*

Oxidative stress, antioxidants and hypertension.

Antioxidants 12:22 (2023)

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As a major cause of morbidity and mortality globally, hypertension remains a serious threat to global public health. Despite the availability of many antihypertensive medications, several hypertensive individuals are resistant to standard treatments, and are unable to control their blood pressure. Regulation of the renin-angiotensin-aldosterone system (RAAS) controlling blood pressure, activation of the immune system triggering inflammation and production of reactive oxygen species, leading to oxidative stress and redox-sensitive signaling, have been implicated in the pathogenesis of hypertension. Thus, besides standard antihypertensive medications, which lower arterial pressure, antioxidant medications were tested to improve antihypertensive treatment. We review and discuss the role of oxidative stress in the pathophysiology of hypertension and the potential use of antioxidants in the management of hypertension and its associated organ damage.

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Publication type Article: Journal article

Document type Review

Corresponding Author

Keywords Antihypertensive Therapy ; Antioxidants ; Cardiovascular Diseases ; Hypertension ; Oxidative Stress ; Reactive Oxygen Species; Alpha-lipoic Acid; Reduces Blood-pressure; Improves Endothelial Function; Salt-induced Hypertension; Dietary Vitamin-e; Supplementation Attenuates Hypertension; Rostral Ventrolateral Medulla; Fructose-induced Hypertension; N-acetylcysteine Treatment; Renin-angiotensin System

ISSN (print) / ISBN 2076-3921

e-ISSN 2076-3921

Journal Antioxidants

Quellenangaben Volume: 12, Issue: 2, Article Number: 22

Publisher MDPI

Publishing Place St Alban-anlage 66, Ch-4052 Basel, Switzerland

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute for Pancreatic Beta Cell Research (IPI)

Grants Excellence Initiative by the German Federal and State Governments
German Centre for Cardiovascular Research (DZHK)
Deutsche Forschungsgemeinschaft (DFG)
Government of Ghana
German Academic Exchange Service (DAAD)