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Amponsah-Offeh, M.* ; Diaba-Nuhoho, P.* ; Speier, S. ; Morawietz, H.*

Oxidative stress, antioxidants and hypertension.

Antioxidants 12:22 (2023)
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As a major cause of morbidity and mortality globally, hypertension remains a serious threat to global public health. Despite the availability of many antihypertensive medications, several hypertensive individuals are resistant to standard treatments, and are unable to control their blood pressure. Regulation of the renin-angiotensin-aldosterone system (RAAS) controlling blood pressure, activation of the immune system triggering inflammation and production of reactive oxygen species, leading to oxidative stress and redox-sensitive signaling, have been implicated in the pathogenesis of hypertension. Thus, besides standard antihypertensive medications, which lower arterial pressure, antioxidant medications were tested to improve antihypertensive treatment. We review and discuss the role of oxidative stress in the pathophysiology of hypertension and the potential use of antioxidants in the management of hypertension and its associated organ damage.
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Publication type Article: Journal article
Document type Review
Keywords Antihypertensive Therapy ; Antioxidants ; Cardiovascular Diseases ; Hypertension ; Oxidative Stress ; Reactive Oxygen Species; Alpha-lipoic Acid; Reduces Blood-pressure; Improves Endothelial Function; Salt-induced Hypertension; Dietary Vitamin-e; Supplementation Attenuates Hypertension; Rostral Ventrolateral Medulla; Fructose-induced Hypertension; N-acetylcysteine Treatment; Renin-angiotensin System
Language english
Publication Year 2023
HGF-reported in Year 2023
ISSN (print) / ISBN 2076-3921
e-ISSN 2076-3921
Journal Antioxidants
Quellenangaben Volume: 12, Issue: 2, Pages: , Article Number: 22 Supplement: ,
Publisher MDPI
Publishing Place St Alban-anlage 66, Ch-4052 Basel, Switzerland
Reviewing status Peer reviewed
Institute(s) Institute of Pancreatic Islet Research (IPI)
POF-Topic(s) 90000 - German Center for Diabetes Research
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502600-005
Grants Excellence Initiative by the German Federal and State Governments
German Centre for Cardiovascular Research (DZHK)
Deutsche Forschungsgemeinschaft (DFG)
Government of Ghana
German Academic Exchange Service (DAAD)
DOI 10.3390/antiox12020281
WOS ID 000938575100001
Scopus ID 85149203311
PubMed ID 36829839
Erfassungsdatum 2023-03-01
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