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Lowe, G.D.O.* ; Harris, K.* ; Koenig, W.* ; Ben-Shlomo, Y.* ; Thorand, B. ; Peters, A. ; Meisinger, C. ; Imhof, A.* ; Tunstall-Pedoe, H.* ; Peters, S.A.E.* ; Woodward, M.*

Plasma viscosity, immunoglobulins and risk of cardiovascular disease and mortality: new data and meta-analyses.

J. Clin. Pathol. 77, 394-401 (2023)
Postprint DOI PMC
Open Access Green
AIMS: Associations of plasma viscosity and plasma Ig levels (a determinant of viscosity) with incident coronary heart disease (CHD) events; and with CHD, cardiovascular disease (CVD: CHD and stroke) and all-cause mortalities. METHODS: Meta-analysis of plasma viscosity levels from the MONitoring of trends and determinants of CArdiovascular (MONICA)/Cooperative Health Research in the Region of Augsburg, MONICA Glasgow and Speedwell Studies; and five other published studies. Meta-analysis of IgA, IgG and IgM levels from the Augsburg, Glasgow and Speedwell studies; and one other published study. RESULTS: Over median follow-up periods of 14-26 years, there were 2270 CHD events, and 4220 all cause deaths in 28 605 participants with baseline plasma viscosity measurements. After adjustment for major risk factors, (HRs; 95% CIs) for a 1 SD increase in viscosity were 1.14 (1.09 to 1.20) for CHD events; and 1.21 (1.17 to 1.25) for all-cause mortality. 821 CHD events and 2085 all-cause deaths occurred in 8218 participants with baseline Ig levels. For CHD events, adjusted HRs for 1 SD increases in IgA, IgG and IgM were, respectively, 0.97 (0.89 to 1.05); 0.95(0.76 to 1.17) and 0.90 (0.79 to 1.03). Corresponding adjusted HRs for all-cause mortality were 1.08 (95% CI 1.02 to 1.13), 1.03 (95% CI 0.94 to 1.14) and 1.01 (95% CI 0.96 to 1.06). CONCLUSIONS: After risk factor adjustment, plasma viscosity was significantly associated with risks of CHD events; and with CHD, CVD and all-cause mortalities. We found no significant association of IgA, IgG or IgM levels with incident CHD events or mortality, except for a borderline association of IgA with all-cause mortality.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Blood Viscosity ; Cardiovascular Diseases ; Immunoglobulins; Myocardial-infarction; Prediction
ISSN (print) / ISBN 0021-9746
e-ISSN 1472-4146
Journal Journal of Clinical Pathology : JCP Online
Quellenangaben Volume: 77, Issue: 6, Pages: 394-401 Article Number: , Supplement: ,
Publisher BMJ Publishing Group
Publishing Place British Med Assoc House, Tavistock Square, London Wc1h 9jr, England
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
Independent Research Group Clinical Epidemiology (KEPI)