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Thorsen, S.U.* ; Liu, X.* ; Kataria, Y.* ; Mandrup-Poulsen, T.* ; Kaur, S.* ; Uusitalo, U.* ; Virtanen, S.M.* ; Norris, J.M.* ; Rewers, M.* ; Hagopian, W.* ; Yang, J.* ; She, J.X.* ; Akolkar, B.* ; Rich, S.* ; Aronsson, C.A.* ; Lernmark, * ; Ziegler, A.-G. ; Toppari, J.* ; Krischer, J.* ; Parikh, H.M.* ; Ellervik, C.* ; Svensson, J.*

Interaction between dietary iron intake and genetically determined iron overload: Risk of islet autoimmunity and progression to Type 1 diabetes in the TEDDY study.

Diabetes Care 46, 1014-1018 (2023)

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Open Access Green as soon as Postprint is submitted to ZB.

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OBJECTIVE: To examine whether iron intake and genetically determined iron overload interact in predisposing to the development of childhood islet autoimmunity (IA) and type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS: In The Environmental Determinants of Diabetes in the Young (TEDDY) study, 7,770 genetically high-risk children were followed from birth until the development of IA and progression to T1D. Exposures included energy-adjusted iron intake in the first 3 years of life and a genetic risk score (GRS) for increased circulating iron. RESULTS: We found a U-shaped association between iron intake and risk of GAD antibody as the first autoantibody. In children with GRS ≥2 iron risk alleles, high iron intake was associated with an increased risk of IA, with insulin as first autoantibody (adjusted hazard ratio 1.71 [95% CI 1.14; 2.58]) compared with moderate iron intake. CONCLUSIONS: Iron intake may alter the risk of IA in children with high-risk HLA haplogenotypes.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Environmental Determinants; Autoantibodies

ISSN (print) / ISBN 0149-5992

e-ISSN 1935-5548

Journal Diabetes Care

Quellenangaben Volume: 46, Issue: 5, Pages: 1014-1018

Publisher American Diabetes Association

Publishing Place Alexandria, Va.

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Diabetes Research Type 1 (IDF)

Grants National Institute of Allergy and Infectious Diseases
Eunice Kennedy Shriver National Institute of Child Health and Human Development
National Institute of Environmental Health Sciences
Centers for Disease Control and Prevention
JDRF
National Institutes of Health/National Center
University of Colorado
Fabrikant Vilhelm Pedersen og Hustrus Mindelegat

National Institute of Diabetes and Digestive and Kidney Diseases