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Xiong, Y.* ; Chu, X.* ; Yu, T.* ; Knoedler, S. ; Schroeter, A.* ; Lu, L.* ; Zha, K.* ; Lin, Z.* ; Jiang, D. ; Rinkevich, Y. ; Panayi, A.C.* ; Mi, B.* ; Liu, G.* ; Zhao, Y.*

Reactive oxygen species-scavenging nanosystems in the treatment of diabetic wounds.

Adv. Healthc. Mater. 12:e2300779 (2023)
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Diabetic wounds are characterized by drug-resistant bacterial infections, biofilm formation, impaired angiogenesis and perfusion, and oxidative damage to the microenvironment. Given their complex nature, diabetic wounds remain a major challenge in clinical practice. Reactive oxygen species (ROS), which have been shown to trigger hyperinflammation and excessive cellular apoptosis, play a pivotal role in the pathogenesis of diabetic wounds. ROS-scavenging nanosystems have recently emerged as smart and multifunctional nanomedicines with broad synergistic applicability. The documented anti-inflammatory and pro-angiogenic ability of ROS-scavenging treatments predestines these nanosystems as promising options for the treatment of diabetic wounds. Yet, in this context, the therapeutic applicability and efficacy of ROS-scavenging nanosystems remain to be elucidated. Herein, the role of ROS in diabetic wounds is deciphered, and the properties and strengths of nanosystems with ROS-scavenging capacity for the treatment of diabetic wounds are summarized. In addition, the current challenges of such nanosystems and their potential future directions are discussed through a clinical-translational lens.
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Publication type Article: Journal article
Document type Review
Keywords Biomedical Nanosystems ; Diabetic Wounds ; Nanomedicine ; Reactive Oxygen Species ; Treatment Mechanisms; Rheumatoid-arthritis; Cells; Microenvironment; Hydrogel; Exosomes; Ros; Nanoparticles; Angiogenesis; Inflammation; Expression
Language english
Publication Year 2023
HGF-reported in Year 2023
ISSN (print) / ISBN 2192-2640
e-ISSN 2192-2659
Journal Advanced healthcare materials
Quellenangaben Volume: 12, Issue: 25, Pages: , Article Number: e2300779 Supplement: ,
Publisher Wiley
Publishing Place Weinheim
Reviewing status Peer reviewed
Institute(s) Institute of Regenerative Biology and Medicine (IRBM)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Lung Research
PSP Element(s) G-509400-001
Grants European Foundation for the Study of Diabetes
DOI 10.1002/adhm.202300779
WOS ID 000979942000001
Scopus ID 85158071987
PubMed ID 37051860
Erfassungsdatum 2023-10-06
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