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Multimorbidity patterns and mortality in older adults: Results from the KORA-Age study.
Front. Nutr. 10:1146442 (2023)
The coexistence of several chronic diseases is very common in older adults, making it crucial to understand multimorbidity (MM) patterns and associated mortality. We aimed to determine the prevalence of MM and common chronic disease combinations, as well as their impact on mortality in men and women aged 65 years and older using the population-based KORA-Age study, based in South of Germany. The chronic disease status of the participants was determined in 2008/9, and mortality status was followed up until 2016. MM was defined as having at least two chronic diseases. We used Cox proportional hazard models to calculate the hazard ratios (HRs) and the 95% confidence intervals (CIs) for associations between MM and all-cause mortality. During the study period 495 men (24.6%) and 368 women (17.4%) died. Although the MM prevalence was almost the same in men (57.7%) and women (60.0%), the overall effect of MM on mortality was higher in men (HR: 1.81, 95% CI: 1.47-2.24) than in women (HR: 1.28, 95% CI: 1.01-1.64; p-value for interaction <0.001). The type of disease included in the MM patterns had a significant impact on mortality risk. For example, when both heart disease and diabetes were included in the combinations of two and three diseases, the mortality risk was highest. The risk of premature death does not only depend on the number of diseases but also on the specific disease combinations. In this study, life expectancy depended strongly on a few diseases, such as diabetes, hypertension, and heart disease.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Chronic Disease ; Hazard Ratios ; Mortality ; Multimorbidity ; Older People ; Sex Differences; All-cause Mortality; Body-mass Index; Sex-differences; Chronic Diseases; Risk; Impact; Obesity; Hypertension; Association; Disability
ISSN (print) / ISBN
2296-861X
e-ISSN
2296-861X
Journal
Frontiers in Nutrition
Quellenangaben
Volume: 10,
Article Number: 1146442
Publisher
Frontiers
Publishing Place
Lausanne
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Epidemiology II (EPI2)
Grants
German Federal Ministry of Education and Research
KORA
Helmholtz Zentrum Muenchen - German Research Center for Environmental Health - German Federal Ministry of Education and Research (BMBF) State Bavaria
KORA
Helmholtz Zentrum Muenchen - German Research Center for Environmental Health - German Federal Ministry of Education and Research (BMBF) State Bavaria