PuSH - Publication Server of Helmholtz Zentrum München: Accounting for blood attenuation in intravascular near-infrared fluorescence-ultrasound imaging using a fluorophore-coated guidewire.

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... Journal

... Publication Type

... Research Data

... Publication Year

Publication overview

Support & Contact

Contact persons

Help

Data protection

Rauschendorfer, P. ; Wissmeyer, G.* ; Jaffer, F.A. ; Gorpas, D. ; Ntziachristos, V.

Accounting for blood attenuation in intravascular near-infrared fluorescence-ultrasound imaging using a fluorophore-coated guidewire.

J. Biomed. Opt. 28:046001 (2023)

Publ. Version/Full Text

DOI

PMC

	Other License

Open Access Green as soon as Postprint is submitted to ZB.

Abstract
Metrics
Extra information

SIGNIFICANCE: Intravascular near-infrared fluorescence (NIRF) imaging aims to improve the inspection of vascular pathology using fluorescent agents with specificity to vascular disease biomarkers. The method has been developed to operate in tandem with an anatomical modality, such as intravascular ultrasound (IVUS), and complements anatomical readings with pathophysiological contrast, enhancing the information obtained from the hybrid examination. AIM: However, attenuation of NIRF signals by blood challenges NIRF quantification. We propose a new method for attenuation correction in NIRF intravascular imaging based on a fluorophore-coated guidewire that is used as a reference for the fluorescence measurement and provides a real-time measurement of blood attenuation during the NIRF examination. APPROACH: We examine the performance of the method in a porcine coronary artery ex vivo and phantoms using a 3.2F NIRF-IVUS catheter. RESULTS: We demonstrate marked improvement over uncorrected signals of up to 4.5-fold and errors of < 11 % for target signals acquired at distances up to 1 mm from the catheter system employed. CONCLUSIONS: The method offers a potential means of improving the accuracy of intravascular NIRF imaging under in vivo conditions.

Altmetric

Additional Metrics?

[➜Log in]

Edit extra informations Login

Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Intravascular Imaging ; Intravascular Ultrasound ; Light Attenuation ; Near-infrared Fluorescence Imaging ; Quantification; Atherosclerosis; Inflammation; Catheter; Ivus

ISSN (print) / ISBN 1083-3668

e-ISSN 1560-2281

Journal Journal of Biomedical Optics

Quellenangaben Volume: 28, Issue: 4, Article Number: 046001

Publisher SPIE

Publishing Place 1000 20th St, Po Box 10, Bellingham, Wa 98225 Usa

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Biological and Medical Imaging (IBMI)

Grants NIH
Deutsche Forschungsgemeinschaft (DFG)
German Center for Cardiovascular Research (DZHK)