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Chavakis, T. ; Alexaki, V.I.* ; Ferrante, A.W.*

Macrophage function in adipose tissue homeostasis and metabolic inflammation.

Nat. Immunol. 24, 757-766 (2023)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Obesity-related metabolic organ inflammation contributes to cardiometabolic disorders. In obese individuals, changes in lipid fluxes and storage elicit immune responses in the adipose tissue (AT), including expansion of immune cell populations and qualitative changes in the function of these cells. Although traditional models of metabolic inflammation posit that these immune responses disturb metabolic organ function, studies now suggest that immune cells, especially AT macrophages (ATMs), also have important adaptive functions in lipid homeostasis in states in which the metabolic function of adipocytes is taxed. Adverse consequences of AT metabolic inflammation might result from failure to maintain local lipid homeostasis and long-term effects on immune cells beyond the AT. Here we review the complex function of ATMs in AT homeostasis and metabolic inflammation. Additionally, we hypothesize that trained immunity, which involves long-term functional adaptations of myeloid cells and their bone marrow progenitors, can provide a model by which metabolic perturbations trigger chronic systemic inflammation.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Necrosis-factor-alpha; Insulin-resistance; Myeloid Cells; Tnf-alpha; Local Proliferation; Obesity; Fat; Stress; Infiltration; Myelopoiesis
ISSN (print) / ISBN 1529-2908
e-ISSN 1529-2916
Journal Nature Immunology
Quellenangaben Volume: 24, Issue: 5, Pages: 757-766 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place Heidelberger Platz 3, Berlin, 14197, Germany
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute for Pancreatic Beta Cell Research (IPI)
Grants Boehringer Ingelheim Pharmaceuticals
Saxon State Ministry of Science, Culture and Tourism-SMWK (Sonderzuweisung zur Unterstuetzung profilbestimmender Struktureinheiten der TUD)
Deutsche Forschungsgemeinschaft
European Research Council (LOSYSINCHRON)