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Chavakis, T. ; Alexaki, V.I.* ; Ferrante, A.W.*

Macrophage function in adipose tissue homeostasis and metabolic inflammation.

Nat. Immunol. 24, 757-766 (2023)
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Obesity-related metabolic organ inflammation contributes to cardiometabolic disorders. In obese individuals, changes in lipid fluxes and storage elicit immune responses in the adipose tissue (AT), including expansion of immune cell populations and qualitative changes in the function of these cells. Although traditional models of metabolic inflammation posit that these immune responses disturb metabolic organ function, studies now suggest that immune cells, especially AT macrophages (ATMs), also have important adaptive functions in lipid homeostasis in states in which the metabolic function of adipocytes is taxed. Adverse consequences of AT metabolic inflammation might result from failure to maintain local lipid homeostasis and long-term effects on immune cells beyond the AT. Here we review the complex function of ATMs in AT homeostasis and metabolic inflammation. Additionally, we hypothesize that trained immunity, which involves long-term functional adaptations of myeloid cells and their bone marrow progenitors, can provide a model by which metabolic perturbations trigger chronic systemic inflammation.
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Publication type Article: Journal article
Document type Review
Keywords Necrosis-factor-alpha; Insulin-resistance; Myeloid Cells; Tnf-alpha; Local Proliferation; Obesity; Fat; Stress; Infiltration; Myelopoiesis
Language english
Publication Year 2023
HGF-reported in Year 2023
ISSN (print) / ISBN 1529-2908
e-ISSN 1529-2916
Journal Nature Immunology
Quellenangaben Volume: 24, Issue: 5, Pages: 757-766 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place Heidelberger Platz 3, Berlin, 14197, Germany
Reviewing status Peer reviewed
Institute(s) Institute of Pancreatic Islet Research (IPI)
POF-Topic(s) 90000 - German Center for Diabetes Research
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502600-008
Grants Boehringer Ingelheim Pharmaceuticals
Saxon State Ministry of Science, Culture and Tourism-SMWK (Sonderzuweisung zur Unterstuetzung profilbestimmender Struktureinheiten der TUD)
Deutsche Forschungsgemeinschaft
European Research Council (LOSYSINCHRON)
DOI 10.1038/s41590-023-01479-0
WOS ID 000962733100002
Scopus ID 85151473348
PubMed ID 37012544
Erfassungsdatum 2023-10-06
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