PuSH - Publication Server of Helmholtz Zentrum München

Thiering, E. ; Markevych, I.* ; Kress, S.* ; Astell-Burt, T.* ; Feng, X.* ; Altug, H.* ; Koletzko, S.* ; Bauer, C.P.* ; von Berg, A.* ; Berdel, D.* ; Herberth, G.* ; Schikowski, T.* ; Heinrich, J.* ; Standl, M.

Gene-environment interaction in the association of residential greenness and 25(OH) vitamin D.

Environ. Pollut. 327:121519 (2023)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
There is increasing awareness for beneficial health effects of green space surrounding the home, but the underlying mechanisms are not yet fully understood and challenging to study given the correlation with other exposures. Here, the association of residential greenness and vitamin D including a gene-environment interaction is investigated. 25-hydroxyvitamin D (25(OH)D) was measured by electrochemiluminescence at ages 10 and 15 years in participants of two German birth cohorts GINIplus and LISA. Greenness was measured using the Landsat-derived Normalized Difference Vegetation Index (NDVI) in a 500 m buffer surrounding the home. Linear and logistic regression models were applied at both time points adjusted for several covariates (N10Y = 2,504, N15Y = 2,613). In additional analyses vitamin D-related genes, physical activity, time spent outdoors, supplements, and measurement season were investigated as potential confounders or effect modifiers. A 1.5-SD increase in NDVI was significantly associated with increased 25(OH)D values at ages 10 and 15 years (β10y = 2.41 nmol/l, p=<0.01; β15y = 2.03 nmol/l, p = 0.02). In stratified analyses, the associations were not seen in participants spending more than 5 h/day outside in summer, having a high physical activity level, taking supplements, or being examined during the winter season. In a subset (n = 1,732) with genetic data, a significant gene-environment interaction of NDVI with CYP2R1, an upstream gene in 25(OH)D synthesis, was observed at age 10 years. When investigating 25(OH)D sufficiency, defined as values above 50 nmol/l, a 1.5-SD increase in NDVI was associated with significantly higher odds of having sufficient 25 (OH)D levels at age 10 years (OR = 1.48, 1.19-1.83). In conclusion, robust associations between residential greenness and 25 (OH)D levels were observed in children and adolescents independent of other confounders and additionally supported by the presence of a gene-environment interaction. Effects of NDVI were stronger in those having lower vitamin D levels at age 10 years due to their covariate profile or genetically lower 25(OH)D synthesis.
Altmetric
Additional Metrics?
Edit extra informations Login
Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords 25(oh)d ; Adolescents ; Epidemiology ; Ndvi ; Residential Greenness ; Vitamin D; Physical-activity; D Deficiency; Children; Impact; Space; Greenspace; Satellite; Pollution; Giniplus; Obesity
ISSN (print) / ISBN 0269-7491
e-ISSN 1873-6424
Quellenangaben Volume: 327, Issue: , Pages: , Article Number: 121519 Supplement: ,
Publisher Elsevier
Publishing Place The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, Oxon, England
Non-patent literature Publications
Reviewing status Peer reviewed
Grants European Regional Development Fund under the Smart Growth Operational Programme
Foundation for Polish Science - EU
University of Wollongong
Federal Ministry of Education and Research (BMBF)
Deutscher Akademischer Austausch Dienst (DAAD)