PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Micolucci, L.* ; Matacchione, G.* ; Albertini, M.C.* ; Marra, M.* ; Ramini, D.* ; Giuliani, A.* ; Sabbatinelli, J.* ; Procopio, A.D.* ; Olivieri, F.* ; Marsico, A. ; Monsurrò, V.*

A data-mining approach to identify NF-kB-responsive microRNAs in tissues involved in inflammatory processes: Potential relevance in age-related diseases.

Int. J. Mol. Sci. 24:26 (2023)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
The nuclear factor NF-kB is the master transcription factor in the inflammatory process by modulating the expression of pro-inflammatory genes. However, an additional level of complexity is the ability to promote the transcriptional activation of post-transcriptional modulators of gene expression as non-coding RNA (i.e., miRNAs). While NF-kB's role in inflammation-associated gene expression has been extensively investigated, the interplay between NF-kB and genes coding for miRNAs still deserves investigation. To identify miRNAs with potential NF-kB binding sites in their transcription start site, we predicted miRNA promoters by an in silico analysis using the PROmiRNA software, which allowed us to score the genomic region's propensity to be miRNA cis-regulatory elements. A list of 722 human miRNAs was generated, of which 399 were expressed in at least one tissue involved in the inflammatory processes. The selection of "high-confidence" hairpins in miRbase identified 68 mature miRNAs, most of them previously identified as inflammamiRs. The identification of targeted pathways/diseases highlighted their involvement in the most common age-related diseases. Overall, our results reinforce the hypothesis that persistent activation of NF-kB could unbalance the transcription of specific inflammamiRNAs. The identification of such miRNAs could be of diagnostic/prognostic/therapeutic relevance for the most common inflammatory-related and age-related diseases.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Altmetric
5.600
0.000
2
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Keywords Nf-kb ; Data-mining ; Inflammation ; Micrornas; Mirna-target Interactions; Dna Helicase Activity; Kappa-b; Transcription; Protein; Expression; Networks; Gene; Perspective; Activation
Language english
Publication Year 2023
HGF-reported in Year 2023
ISSN (print) / ISBN 1661-6596
e-ISSN 1422-0067
Journal International Journal of Molecular Sciences
Quellenangaben Volume: 24, Issue: 6, Pages: , Article Number: 26 Supplement: ,
Publisher MDPI
Publishing Place Basel
Reviewing status Peer reviewed
Institute(s) Institute of Computational Biology (ICB)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-503800-001
Grants Universita Politecnica delle Marche, Italy (RSA)
Italian Ministry of Health
DOI 10.3390/ijms24065123
WOS ID 000958778500001
Scopus ID 85151113117
PubMed ID 36982191
Erfassungsdatum 2023-10-06
[➜Report correction]